The Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models

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dc.contributor.author Brito, Marlon V. [UNIFESP]
dc.contributor.author Oliveira, Cleide de [UNIFESP]
dc.contributor.author Salu, Bruno R. [UNIFESP]
dc.contributor.author Andrade, Sonia A.
dc.contributor.author Malloy, Paula M. D. [UNIFESP]
dc.contributor.author Sato, Ana C. [UNIFESP]
dc.contributor.author Vicente, Cristina P.
dc.contributor.author Sampaio, Misako U. [UNIFESP]
dc.contributor.author Maffei, Francisco H. A. [UNIFESP]
dc.contributor.author Oliva, Maria Luiza V. [UNIFESP]
dc.date.accessioned 2016-01-24T14:37:16Z
dc.date.available 2016-01-24T14:37:16Z
dc.date.issued 2014-05-01
dc.identifier http://dx.doi.org/10.1016/j.thromres.2014.02.027
dc.identifier.citation Thrombosis Research. Oxford: Pergamon-Elsevier B.V., v. 133, n. 5, p. 945-951, 2014.
dc.identifier.issn 0049-3848
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37742
dc.description.abstract The Bauhinia bauhinioides Kallikrein Inhibitor (BbKI) is a Kunitz-type serine peptidase inhibitor of plant origin that has been shown to impair the viability of some tumor cells and to feature a potent inhibitory activity against human and rat plasma kallikrein (Kiapp 2.4 nmol/L and 5.2 nmol/L, respectively). This inhibitory activity is possibly responsible for an effect on hemostasis by prolonging activated partial thromboplastin time (aPTT). Because the association between cancer and thrombosis is well established, we evaluated the possible antithrombotic activity of this protein in venous and arterial thrombosis models. Vein thrombosis was studied in the vena cava ligature model in Wistar rats, and arterial thrombosis in the photochemical induced endothelium lesion model in the carotid artery of C57 black 6 mice. BbKI at a concentration of 2.0 mg/kg reduced the venous thrombus weight by 65% in treated rats in comparison to rats in the control group. the inhibitor prolonged the time for total artery occlusion in the carotid artery model mice indicating that this potent plasma kallikrein inhibitor prevented thrombosis. (C) 2014 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 945-951
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Thrombosis Research
dc.rights Acesso restrito
dc.subject Blood coagulation en
dc.subject Kallikrein en
dc.subject Kunitz inhibitor en
dc.subject Thrombosis en
dc.subject Trypsin inhibitor en
dc.subject Tumor cells en
dc.title The Kallikrein Inhibitor from Bauhinia bauhinioides (BbKI) shows antithrombotic properties in venous and arterial thrombosis models en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Inst Butantan
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.affiliation Inst Butantan, Lab Bioquim & Biofis, BR-05503900 São Paulo, Brazil
dc.description.affiliation Univ Estadual Campinas, Inst Biol, BR-13083863 Campinas, SP, Brazil
dc.description.affiliation UNESP, Fac Med Botucatu, Dept Cirurgia & Ortopedia, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Bioquim, BR-04044020 São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2009/53766-5
dc.description.sponsorshipID FAPESP: 2012/23640-2
dc.identifier.doi 10.1016/j.thromres.2014.02.027
dc.description.source Web of Science
dc.identifier.wos WOS:000334739100038



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