Selenium inadequacy is not associated with oxidative stress in child and adolescent acute lymphocytic leukemia survivors

Selenium inadequacy is not associated with oxidative stress in child and adolescent acute lymphocytic leukemia survivors

Author Sousa Almondes, Kaluce Goncalves de Google Scholar
Oliveira, Tiago Franco de Google Scholar
Siviero-Miachon, Adriana Aparecida Autor UNIFESP Google Scholar
Martino Lee, Maria Lucia de Autor UNIFESP Google Scholar
Carvalho Rondo, Patricia Helen de Google Scholar
Melo Loureiro, Ana Paula de Google Scholar
Spinola-Castro, Angela Maria Autor UNIFESP Google Scholar
Franciscato Cozzolino, Silvia Maria Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: Acute lymphocytic leukemia (ALL) and its subsequent treatment may provoke increased oxidative stress. the aim of this study was to investigate the antioxidant status of children and adolescents who had received ALL therapy, and to test the hypothesis that selenium (Se) inadequacy is correlated with reduced defenses against oxidative stress in this population.Methods: This case-control study involved 24 patients between ages 5 and 13 y who had been treated successfully for ALL (ALL group) and 60 children of similar age and socioeconomic background with no clinical history of leukemia (control group). Dietary intake of Se was evaluated by the 24-h recall method, and the concentrations of Se in plasma, erythrocytes, and urine determined. Antioxidant status was assessed by analysis of the oxidative stress markers, namely, superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), alpha-tocopherol, and 8-oxo-deoxyguanosine (8-oxo-dG).Results: There were no between-group differences with respect to plasma (P = 0.122), erythrocyte (P = 0.202), urinary (P = 0.608), or dietary (P = 0.757) levels of Se. GPx activity was significantly (P < 0.001) reduced in the ALL group compared with the control group, whereas SOD activity and MDA concentrations were similar. the concentrations of alpha-tocopherol and 8-oxo-dG were significantly increased in the ALL group compared with the control group (P < 0.001 and P = 0.031, respectively).Conclusion: All participants were Se inadequate, but such inadequacy was not correlated with reduced defenses against oxidative stress. However, individuals of the ALL group were with increased oxidative stress compared with the control group, possibly due to previous disease and to intensive polychemotherapy. (C) 2014 Elsevier Inc. All rights reserved.
Keywords Acute lymphoblastic leukemia
Selenium
Oxidative stress
Antioxidants
DNA damage
Chemotherapy
Language English
Date 2014-05-01
Published in Nutrition. New York: Elsevier B.V., v. 30, n. 5, p. 563-568, 2014.
ISSN 0899-9007 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 563-568
Origin http://dx.doi.org/10.1016/j.nut.2013.10.012
Access rights Closed access
Type Article
Web of Science ID WOS:000334479800011
URI http://repositorio.unifesp.br/handle/11600/37738

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