B-1 cells and concomitant immunity in Ehrlich tumour progression

B-1 cells and concomitant immunity in Ehrlich tumour progression

Autor Azevedo, M. C. Autor UNIFESP Google Scholar
Palos, M. C. Autor UNIFESP Google Scholar
Osugui, L. Autor UNIFESP Google Scholar
Laurindo, M. F. Autor UNIFESP Google Scholar
Masutani, D. Autor UNIFESP Google Scholar
Nonogaki, S. Autor UNIFESP Google Scholar
Bachi, A. L. L. Autor UNIFESP Google Scholar
Melo, F. H. M. Autor UNIFESP Google Scholar
Mariano, M. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Concomitant immunity is a phenomenon in which a tumour-bearing host is resistant to the growth of an implanted secondary tumour. Metastases are considered to be secondary tumours that develop spontaneously during primary tumour growth, suggesting the involvement of concomitant immunity in controlling the rise of metastases. It has been demonstrated that B-1 cells, a subset of B-lymphocytes found predominantly in pleural and peritoneal cavities, not only increase the metastatic development of murine melanoma B16F10, but also are capable of differentiating into mononuclear phagocytes, modulating inflammatory responses in wound healing, in oral tolerance and in Paracoccidiose brasiliensis infections. Here, we studied B-1 cells' participation in concomitant immunity during Ehrlich tumour progression. Our results show that B-1 cells obtained from BALB/c mice previously injected with Ehrlich tumour in the footpad were able to protect BALB/c and BALB/Xid mice against Ehrlich tumour challenge. in addition, it was demonstrated that BALB/Xid show faster tumour growth and have lost concomitant immunity, and that this state can be partially restored by reconstituting these animals with B-1 cells. However, further researches are required to establish the mechanism involving B-1 cells in Ehrlich tumour growth. (C) 2014 Elsevier GmbH. All rights reserved.
Palavra-chave Adoptive transfer
B-1 cells
Cancer
Concomitant immunity
Ehrlich tumour
Idioma Inglês
Data de publicação 2014-05-01
Publicado em Immunobiology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 219, n. 5, p. 357-366, 2014.
ISSN 0171-2985 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 357-366
Fonte http://dx.doi.org/10.1016/j.imbio.2013.12.001
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000334480300004
Endereço permanente http://repositorio.unifesp.br/handle/11600/37731

Exibir registro completo




Arquivo

Arquivo Tamanho Formato Visualização

Não existem arquivos associados a este item.

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta