Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil

Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil

Author Soares de Araujo, Rubistenia Miranda Google Scholar
Vieira de Melo, Cynthia Farias Google Scholar
Manes Neto, Fidelis Google Scholar
Silva, Juarez Nobrega da Google Scholar
Soares, Leonardo Ferreira Google Scholar
Cardoso Smith, Marilia de Arruda Autor UNIFESP Google Scholar
Sousa, Edilson Carvalho Google Scholar
Rodriguez Burbano, Rommel Mario Google Scholar
Medeiros, Arnaldo Correia de Google Scholar
Lima, Eleonidas Moura Google Scholar
Institution Universidade Federal da Paraíba (UFPB)
Hosp Sao Marcos
State Univ Paraiba UEPB
Universidade Federal de São Paulo (UNIFESP)
Fed Univ Para
Abstract Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1, GSTT1, and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. the results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher's exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed (chi (2) = 8.73, P < 0.05). Our results suggest that the GSTP1 gene SNP (rs1695) can be considered a risk factor associated with gastric carcinogenesis.
Keywords SNPs
Gastric cancer
GSTP1
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2014-05-01
Published in Tumor Biology. Dordrecht: Springer, v. 35, n. 5, p. 4983-4986, 2014.
ISSN 1010-4283 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 4983-4986
Origin http://dx.doi.org/10.1007/s13277-014-1656-z
Access rights Closed access
Type Article
Web of Science ID WOS:000335759800122
URI http://repositorio.unifesp.br/handle/11600/37722

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