Values of Beta-human chorionic gonadotrofin as a risk factor for tubal pregnancy rupture evaluated by histopathology

Values of Beta-human chorionic gonadotrofin as a risk factor for tubal pregnancy rupture evaluated by histopathology

Author Elito Junior, Julio Autor UNIFESP Google Scholar
Ferreira, Danyelle Farias Autor UNIFESP Google Scholar
Araujo Junior, Edward Autor UNIFESP Google Scholar
Stavale, Joao Norberto Autor UNIFESP Google Scholar
Camano, Luiz Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To evaluate the depth of trophoblastic infiltration in tubal wall in ectopic pregnancy (EP) assessed by histopathology and their correlation with initial values of beta-hCG.Methods: A prospective study including 27 patients with diagnosis of EP was realized. the tubal pregnancies were histologically classified according to the depth of infiltration of trophoblastic tissue on the wall of the tube (stage I: limited to mucosa; stage II: reaching the muscularis layer; stage III: complete infiltration of the tubal wall). the comparison between groups for numeric variables was performed by ANOVA. the receiver operating characteristic (ROC) curve was performed to obtain the cutoff value of beta-hCG associated with the degree of trophoblast invasion into the wall of the tube evaluated by histology.Results: the mean beta-hCG in patients evaluated by histopathology as stage I + II was 2868 mIU/ml and stage III was 11 202 mIU/ml (p = 0.017). beta-hCG levels that best predicted for stage III was 2906 mIU/ml, with a sensitivity of 85.7% and a specificity of 69.2%.Conclusion: There is a direct correlation between serum beta-hCG and the depth of trophoblast infiltration of the tube wall at histopathology.
Keywords Beta fraction of chorionic gonadotrophin
ectopic pregnancy
first trimester hemorrhage
trophoblast infiltration
Language English
Date 2014-04-01
Published in Journal of Maternal-fetal & Neonatal Medicine. London: Informa Healthcare, v. 27, n. 6, p. 637-639, 2014.
ISSN 1476-7058 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 637-639
Access rights Closed access
Type Article
Web of Science ID WOS:000332728600022

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