Early weight gain and the development of asthma and atopy in children

Early weight gain and the development of asthma and atopy in children

Author Wandalsen, Gustavo F. Autor UNIFESP Google Scholar
Chong-Neto, Herberto J. Google Scholar
Souza, Fabiola S. de Autor UNIFESP Google Scholar
Sole, Dirceu Autor UNIFESP Google Scholar
Bacharier, Leonard B. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Parana
ABC Med Sch
Washington Univ
St Louis Childrens Hosp
Abstract Purpose of reviewTo provide perspective to the most recent evidence regarding the association between early weight gain in infancy and the development of asthma and atopy during childhood, and highlight the potential mechanisms involved.Recent findingsRecently, several birth cohort studies involving more than 25000 children have found a consistent association between early weight gain in the first 2 years of life and incident asthma during school age. Methodology differs substantially between the studies and complicates the establishment of definite conclusions. Specific mechanisms for this association have been proposed, including impairment in lung development and elevated levels of growth factors and cytokines associated with airway inflammation and remodeling. A limited number of studies indicate that early weight gain in infancy is also associated with recurrent wheezing during preschool age but not with the development of atopy.SummaryA consistent association between early weight gain in infancy and incident asthma during school age has been observed in several cohort studies. the identification of this modifiable risk factor for the development of asthma opens the possibility of preventive intervention. Additional studies are necessary to clarify the involved mechanisms and some pending questions, such as the influence of early weight gain in asthma phenotypes and severity.
Keywords asthma
children
obesity
weight gain
wheezing
Language English
Date 2014-04-01
Published in Current Opinion in Allergy and Clinical Immunology. Philadelphia: Lippincott Williams & Wilkins, v. 14, n. 2, p. 126-130, 2014.
ISSN 1528-4050 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 126-130
Origin http://dx.doi.org/10.1097/ACI.0000000000000037
Access rights Closed access
Type Review
Web of Science ID WOS:000333256200008
URI http://repositorio.unifesp.br/handle/11600/37638

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