Cytogenetic biomonitoring of oral mucosa cells of crack cocaine users

Cytogenetic biomonitoring of oral mucosa cells of crack cocaine users

Author Alonso de Oliveira, Maria das Gracas Google Scholar
Santos, Jean Nunes dos Google Scholar
Cury, Patricia Ramos Google Scholar
Pereira da Silva, Victor Hugo Autor UNIFESP Google Scholar
Cruz Oliveira, Nara Rejane Autor UNIFESP Google Scholar
Padovani, Ricardo da Costa Autor UNIFESP Google Scholar
Tucci, Adriana Marcassa Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Univ Fed Bahia
Universidade Federal da Bahia (UFBA)
Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of the present study was to comparatively evaluate genomic damage (micronucleus) and cellular death (pyknosis, karyolysis, and karyorrhexis) in exfoliated oral mucosa cells from crack cocaine users by micronucleus test. A total of 30 crack cocaine users and 30 health controls (non-exposed individuals) were included in this setting. Individuals had epithelial cells from cheek mechanically exfoliated, placed in fixative, and dropped in clean slides, which were checked for the above nuclear phenotypes. the results pointed out significant statistical differences (p < 0.05) of micronucleated oral mucosa cells from crack cocaine users. Exposure to crack cocaine caused an increase of other nuclear alterations closely related to cytotoxicity such as karyolysis in oral cells as well. in summary, these data indicate that crack cocaine is able to induce chromosomal breakage and cellular death in oral mucosa cells of users.
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2014-04-01
Published in Environmental Science and Pollution Research. Heidelberg: Springer Heidelberg, v. 21, n. 8, p. 5760-5764, 2014.
ISSN 0944-1344 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 5760-5764
Origin http://dx.doi.org/10.1007/s11356-013-2447-6
Access rights Closed access
Type Article
Web of Science ID WOS:000334443600046
URI http://repositorio.unifesp.br/handle/11600/37603

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