Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet

Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet

Author Moreno, Mayara Franzoi Autor UNIFESP Google Scholar
Souza, Gabriel Inacio de Morais Honorato de Autor UNIFESP Google Scholar
Hachul, Ana Claudia Losinskas Autor UNIFESP Google Scholar
Santos, Bruno dos Autor UNIFESP Google Scholar
Okuda, Marcos Hiromu Autor UNIFESP Google Scholar
Pinto Neto, Nelson Inacio Autor UNIFESP Google Scholar
Boldarine, Valter Tadeu Autor UNIFESP Google Scholar
Esposito, Elisa Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Ganen, Aline de Piano Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. the aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet.Methods: Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks [groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)].Results: the high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-kappa B p50. in HC we observed a positive correlation between IL-10 and TNF-alpha in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue.Conclusions: High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu.
Keywords Mesenteric adipose tissue
Cytokines
IL-10
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2011/04310-9
Date 2014-03-28
Published in Nutrition & Metabolism. London: Biomed Central Ltd, v. 11, 9 p., 2014.
ISSN 1743-7075 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 9
Origin http://dx.doi.org/10.1186/1743-7075-11-15
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000334947700001
URI http://repositorio.unifesp.br/handle/11600/37564

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