Aerobic Plus Resistance Training Improves Bone Metabolism and Inflammation in Adolescents who Are Obese

Aerobic Plus Resistance Training Improves Bone Metabolism and Inflammation in Adolescents who Are Obese

Author Campos, Raquel M. S. Autor UNIFESP Google Scholar
Mello, Marco T. de Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Silva, Patricia L. Autor UNIFESP Google Scholar
Masquio, Deborah C. L. Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Sanches, Priscila L. Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Corgosinho, Flavia C. Autor UNIFESP Google Scholar
Foschini, Denis Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Damaso, Ana R. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Campos, RMS, de Mello, MT, Tock, L, Silva, PL, Masquio, DCL, de Piano, A, Sanches, PL, Carnier, J, Corgosinho, FC, Foschini, D, Tufik, S, and Damaso, AR. Aerobic plus resistance training improves bone metabolism and inflammation in adolescents who are obese. J Strength Cond Res 28(3): 758-766, 2014-Obesity is a worldwide epidemic with a high prevalence of comorbidities, including alterations in bone mineral metabolism. the purpose of this yearlong study was to evaluate the role of 2 types of exercise training (aerobic and aerobic plus resistance exercise) on adipokines parameters and bone metabolism in adolescents who are obese. This was a clinical trial study with interdisciplinary weight loss therapy. Forty-two postpubertal adolescents who are obese were subjected to interdisciplinary weight loss therapy with physical exercise, medical monitoring, nutritional intervention, and psychological intervention. Data were collected from serum analyses of leptin, ghrelin, adiponectin, glucose, and insulin. Anthropometric measurements of body composition, bone mineral density, visceral, and subcutaneous fat were also performed. Statistical tests were applied using repeated-measures analysis of variance. Correlations were established using the Pearson test, and dependencies of variables were established using simple linear regression test. Both training types promoted reductions in body mass index, total central, visceral and subcutaneous fat, insulin concentration, and homeostasis model assessment insulin resistance (HOMA-IR) index, but only aerobic plus resistance training showed statistical improvements in the bone mineral content, adiponectin concentration, and lean tissue. Effective reduction in the visceral/subcutaneous ratio, central/peripheral ratio, and leptin concentration was observed. Insulin and the HOMA-IR index were negative predictors of bone mineral content in the combined training group. Moreover, fat distribution was a negative predictor for bone mineral density in both groups. Aerobic plus resistance training promotes a protective role in bone mineral content associated with an improvement in adiponectin and leptin concentrations, favoring the control of the inflammatory state related to obesity in adolescents. Aerobic plus resistance training combined with interdisciplinary interventions provides important strategies to approach obesity, and these strategies may contribute to clinical practice.
Keywords bone mass
aerobic training
obesity
adipokines
resistance training
Language English
Sponsor AFIP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
UNIFESP-EPM
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: CEPID/Sleep 9814303-3
FAPESP: 2006/00684-3
FAPESP: 2008/53069-0
FAPESP: 2011/50356-0
FAPESP: 2011/50414-0
CAPES: PNPD 2566/2011
Date 2014-03-01
Published in Journal of Strength and Conditioning Research. Philadelphia: Lippincott Williams & Wilkins, v. 28, n. 3, p. 758-766, 2014.
ISSN 1064-8011 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 758-766
Origin http://dx.doi.org/10.1519/JSC.0b013e3182a996df
Access rights Closed access
Type Article
Web of Science ID WOS:000332153100022
URI http://repositorio.unifesp.br/handle/11600/37531

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