Relationships between sleep and addiction: the role of drug-environment conditioning

Relationships between sleep and addiction: the role of drug-environment conditioning

Autor Berro, Lais F. Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Addiction to cocaine and other amphetamine-like psychostimulants is a chronic relapsing disorder characterized by loss of control over drug taking. Sleep disturbance is common among patients in recovery from drug abuse and can precipitate relapse. It has been widely demonstrated that sleep deprivation and psychostimulants share similar neurobiological effects regarding the dopaminergic system. in addition, the persistence of a drug-environment conditioning induced by repeated psychostimulant treatment, which is deeply related to the dopaminergic neurotransmission, is thought to play a key role in the addictive cycle. in this scenario, we hypothesized that sleep deprivation is a potential detrimental factor to the extinction process of previously established drug-environment conditioning. Therefore, sleep deprivation would extend the pairing between the cocaine reinforcing effects and the environmental cues, thereby leading drug abusers to relapse. (C) 2014 Elsevier B.V. All rights reserved.
Idioma Inglês
Financiador Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 2011/16580-0
Data de publicação 2014-03-01
Publicado em Medical Hypotheses. Edinburgh: Churchill Livingstone, v. 82, n. 3, p. 374-376, 2014.
ISSN 0306-9877 (Sherpa/Romeo, fator de impacto)
Publicador Churchill Livingstone
Extensão 374-376
Fonte http://dx.doi.org/10.1016/j.mehy.2013.12.026
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000333494100025
Endereço permanente http://repositorio.unifesp.br/handle/11600/37494

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