Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae)

Antimicrobial, antioxidant and cytotoxic activities of propolis from Melipona orbignyi (Hymenoptera, Apidae)

Author Campos, Jaqueline Ferreira Google Scholar
Santos, Uilson Pereira dos Google Scholar
Benitez Macorini, Luis Fernando Google Scholar
Mestriner Felipe de Melo, Adriana Mary Google Scholar
Perrella Balestieri, Jose Benedito Google Scholar
Paredes-Gamero, Edgar Julian Autor UNIFESP Google Scholar
Lima Cardoso, Claudia Andrea Google Scholar
Souza, Kely de Picoli Google Scholar
Santos, Edson Lucas dos Google Scholar
Institution Fed Univ Grande Dourados
Univ Ctr Grande Dourados
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Mato Grosso do Sul (UEMS)
Abstract Propolis from stingless bees is well known for its biologic properties; however, few studies have demonstrated these effects. Therefore, this study aimed to investigate the chemical composition and antimicrobial, antioxidant and cytotoxic activities of propolis from the stingless bee Melipona orbignyi, found in Mato Grosso do Sul, Brazil. the chemical composition of the ethanol extract of propolis (EEP) indicated the presence of aromatic acids, phenolic compounds, alcohols, terpenes and sugars. the EEP was active against the bacterium Staphylococcus aureus and the fungus Candida albicans. the EEP showed antioxidant activity by scavenging free radicals and inhibiting hemolysis and lipid peroxidation in human erythrocytes incubated with an oxidizing agent. Additionally, EEP promoted cytotoxic activity and primarily necrotic death in K562 erythroleukemia cells. Taken together, these results indicate that propolis from M. orbignyi has therapeutic potential for the treatment and/or prevention of diseases related to microorganism activity, oxidative stress and tumor cell proliferation. (C) 2014 Elsevier B.V. All rights reserved.
Keywords Stingless bee
Oxidative stress
Hemolysis
Lipid peroxidation
Necrosis
Anti-tumor activity
Language English
Sponsor Development of Education, Science and Technology of Mato Grosso do Sul State - FUNDECT
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
FUNDECT
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number Development of Education, Science and Technology of Mato Grosso do Sul State - FUNDECT: 23/200.729/2012
CNPq: 482661/2013-5
Date 2014-03-01
Published in Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 65, p. 374-380, 2014.
ISSN 0278-6915 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 374-380
Origin http://dx.doi.org/10.1016/j.fct.2014.01.008
Access rights Closed access
Type Article
Web of Science ID WOS:000332500500045
URI http://repositorio.unifesp.br/handle/11600/37489

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