Major components of metabolic syndrome and adiponectin levels: a cross-sectional study

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dc.contributor.author von Frankenberg, Anize D.
dc.contributor.author Nascimento, Filipe V. do
dc.contributor.author Gatelli, Lucas Eduardo
dc.contributor.author Nedel, Barbara L.
dc.contributor.author Garcia, Sheila P.
dc.contributor.author Oliveira, Carolina S. V. de [UNIFESP]
dc.contributor.author Saddi-Rosa, Pedro [UNIFESP]
dc.contributor.author Reis, Andre F. [UNIFESP]
dc.contributor.author Canani, Luis H.
dc.contributor.author Gerchman, Fernando
dc.date.accessioned 2016-01-24T14:35:19Z
dc.date.available 2016-01-24T14:35:19Z
dc.date.issued 2014-02-26
dc.identifier http://dx.doi.org/10.1186/1758-5996-6-26
dc.identifier.citation Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 9 p., 2014.
dc.identifier.issn 1758-5996
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37446
dc.description.abstract Background: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. the purpose of the study was to investigate the relationship between adiponectin levels and MS.Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clinicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured.Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001).Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity. en
dc.description.sponsorship Foundation for Research Support of the State of Rio Grande do Sul (FAPERGS)
dc.description.sponsorship Hospital de Clinicas de Porto Alegre Research Fund
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship International Scholarship Program of the Endocrine Society
dc.format.extent 9
dc.language.iso eng
dc.publisher Biomed Central Ltd
dc.relation.ispartof Diabetology & Metabolic Syndrome
dc.rights Acesso aberto
dc.subject Adiponectin en
dc.subject Metabolic syndrome en
dc.subject Obesity en
dc.title Major components of metabolic syndrome and adiponectin levels: a cross-sectional study en
dc.type Artigo
dc.contributor.institution Univ Fed Rio Grande do Sul
dc.contributor.institution Hosp Clin Porto Alegre
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Rio Grande do Sul, Fac Med, Postgrad Endocrinol Program, Porto Alegre, RS, Brazil
dc.description.affiliation Hosp Clin Porto Alegre, Metab Unit, Div Endocrinol, Porto Alegre, RS, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Endocrinol Unit, São Paulo, Brazil
dc.description.affiliation Hosp Clin Porto Alegre, BR-90035003 Porto Alegre, RS, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Endocrinol Unit, São Paulo, Brazil
dc.description.sponsorshipID Hospital de Clinicas de Porto Alegre Research Fund: FIPE 11-226
dc.identifier.file WOS000334382200001.pdf
dc.identifier.doi 10.1186/1758-5996-6-26
dc.description.source Web of Science
dc.identifier.wos WOS:000334382200001



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