Major components of metabolic syndrome and adiponectin levels: a cross-sectional study

Major components of metabolic syndrome and adiponectin levels: a cross-sectional study

Author von Frankenberg, Anize D. Google Scholar
Nascimento, Filipe V. do Google Scholar
Gatelli, Lucas Eduardo Google Scholar
Nedel, Barbara L. Google Scholar
Garcia, Sheila P. Google Scholar
Oliveira, Carolina S. V. de Autor UNIFESP Google Scholar
Saddi-Rosa, Pedro Autor UNIFESP Google Scholar
Reis, Andre F. Autor UNIFESP Google Scholar
Canani, Luis H. Google Scholar
Gerchman, Fernando Google Scholar
Institution Univ Fed Rio Grande do Sul
Hosp Clin Porto Alegre
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Adiponectin is a major regulator of glucose and lipid homeostasis by its insulin sensitizer properties. Since decreased insulin sensitivity is linked to metabolic syndrome (MS), decreased adiponectin levels may be related to its development. the purpose of the study was to investigate the relationship between adiponectin levels and MS.Methods: Firstly, we cross-sectionally examined subjects with or without MS submitted to an oral glucose tolerance test at Hospital de Clinicas de Porto Alegre (n = 172). A replication analysis was performed in subjects (n = 422) undergoing cardiac angiography at Hospital São Paulo. Subchronic inflammation (US-CRP), coagulation marker (fibrinogen), insulin sensitivity and resistance (Matsuda ISI and HOMA-IR) were estimated. Plasma total and high molecular weight (HMW) adiponectin were measured.Results: Total and HMW adiponectin levels were lower in MS subjects (P < 0.05). Total adiponectin levels were lower in the presence of high waist circumference, low HDL-cholesterol and elevated triglyceride criteria in both samples and by elevated blood pressure and glucose criteria in Porto Alegre. HMW adiponectin levels were lower in the presence of low HDL-cholesterol, elevated triglycerides, and glucose criteria. Total adiponectin levels were positively related with HDL-cholesterol and ISI Matsuda, negatively related with waist circumference, glucose, triglycerides, HOMA-IR, and US-CRP and not related with blood pressure. While adjusting for sex and age, increased adiponectin levels remained associated with a reduced prevalence ratio for MS in both cohorts (P = 0.001).Conclusions: Adiponectin levels decreased with increasing number of MS criteria, and it is in part determined by its relationship with HDL, triglycerides and abdominal adiposity.
Keywords Adiponectin
Metabolic syndrome
Language English
Sponsor Foundation for Research Support of the State of Rio Grande do Sul (FAPERGS)
Hospital de Clinicas de Porto Alegre Research Fund
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
International Scholarship Program of the Endocrine Society
Grant number Hospital de Clinicas de Porto Alegre Research Fund: FIPE 11-226
Date 2014-02-26
Published in Diabetology & Metabolic Syndrome. London: Biomed Central Ltd, v. 6, 9 p., 2014.
ISSN 1758-5996 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 9
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000334382200001

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