Optical Coherence Tomography Combined With Videokeratography to Differentiate Mild Keratoconus Subtypes

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dc.contributor.author Rabinowitz, Yaron S.
dc.contributor.author Li, Xiaohui
dc.contributor.author Caiado Canedo, Ana Laura
dc.contributor.author Ambrosio, Renato [UNIFESP]
dc.contributor.author Bykhovskaya, Yelena
dc.date.accessioned 2016-01-24T14:35:17Z
dc.date.available 2016-01-24T14:35:17Z
dc.date.issued 2014-02-01
dc.identifier http://dx.doi.org/10.3928/1081597X-20140120-02
dc.identifier.citation Journal of Refractive Surgery. Thorofare: Slack Inc, v. 30, n. 2, p. 80-+, 2014.
dc.identifier.issn 1081-597X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37424
dc.description.abstract PURPOSE: To develop parameters using a combination of optical coherence tomography (OCT) and videokeratography to detect early keratoconus.METHODS: Videokeratography, wavefront analysis, and measured OCT indices were performed on 180 normal eyes, 46 eyes with moderate keratoconus, 54 eyes with early keratoconus, 7 eyes with forme fruste keratoconus, and 16 eyes with keratoconus suspect to determine the most sensitive parameters for separating these groups.RESULTS: A combination of videokeratography and OCT indices (inferior-superior [I-S] value and minimum pachymetry) was statistically the most significant in separating the keratoconus groups from normal eyes (P < .001). Using a newly derived index, the minimum pachymetry divided by the I-S value (pachymetry/asymmetry [PA]/I-S index) with a cut-off of 100, 100% of early and forme fruste keratoconus could be identified as being abnormal with 7 normals misclassified (misclassification rate 2.7%). By adding keratoconus suspect to the analysis and an I-S value of 1.2 as a cut-off point, 5 suspects were classified as normal and 11 normals as abnormal (misclassification rate 7.8%). the PA/I-S index, with a cut-off point of 100, reduced this misclassification rate to 4.4%.CONCLUSIONS: These results suggest that OCT combined with videokeratography may be more useful for differentiating mild forms of keratoconus than videokeratography alone. en
dc.description.sponsorship National Eye Institutes of Health
dc.description.sponsorship Skirball Foundation for Molecular Ophthalmology, Los Angeles, California
dc.description.sponsorship Eye Defects Research Foundation Inc., Beverly Hills, California
dc.format.extent 80-+
dc.language.iso eng
dc.publisher Slack Inc
dc.relation.ispartof Journal of Refractive Surgery
dc.rights Acesso restrito
dc.title Optical Coherence Tomography Combined With Videokeratography to Differentiate Mild Keratoconus Subtypes en
dc.type Artigo
dc.contributor.institution Cornea Genet Eye Inst
dc.contributor.institution Cedars Sinai Med Ctr
dc.contributor.institution Harbor UCLA Med Ctr
dc.contributor.institution Univ Calif Los Angeles
dc.contributor.institution Inst Olhos Renato Ambrosio
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Cornea Genet Eye Inst, Beverly Hills, CA USA
dc.description.affiliation Cedars Sinai Med Ctr, Regenerat Med Inst, Los Angeles, CA 90048 USA
dc.description.affiliation Harbor UCLA Med Ctr, Los Angeles BioMed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA
dc.description.affiliation Univ Calif Los Angeles, Jules Stein Eye Inst, Los Angeles, CA 90024 USA
dc.description.affiliation Inst Olhos Renato Ambrosio, Rio de Janeiro, Brazil
dc.description.affiliation Univ São Paulo, UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifesp Univ São Paulo, UNIFESP, São Paulo, Brazil
dc.description.sponsorshipID National Eye Institutes of Health: NEI-RO1-09052
dc.identifier.doi 10.3928/1081597X-20140120-02
dc.description.source Web of Science
dc.identifier.wos WOS:000331909400002


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