Optical Coherence Tomography Combined With Videokeratography to Differentiate Mild Keratoconus Subtypes

Optical Coherence Tomography Combined With Videokeratography to Differentiate Mild Keratoconus Subtypes

Author Rabinowitz, Yaron S. Google Scholar
Li, Xiaohui Google Scholar
Caiado Canedo, Ana Laura Google Scholar
Ambrosio, Renato Autor UNIFESP Google Scholar
Bykhovskaya, Yelena Google Scholar
Institution Cornea Genet Eye Inst
Cedars Sinai Med Ctr
Harbor UCLA Med Ctr
Univ Calif Los Angeles
Inst Olhos Renato Ambrosio
Universidade Federal de São Paulo (UNIFESP)
Abstract PURPOSE: To develop parameters using a combination of optical coherence tomography (OCT) and videokeratography to detect early keratoconus.METHODS: Videokeratography, wavefront analysis, and measured OCT indices were performed on 180 normal eyes, 46 eyes with moderate keratoconus, 54 eyes with early keratoconus, 7 eyes with forme fruste keratoconus, and 16 eyes with keratoconus suspect to determine the most sensitive parameters for separating these groups.RESULTS: A combination of videokeratography and OCT indices (inferior-superior [I-S] value and minimum pachymetry) was statistically the most significant in separating the keratoconus groups from normal eyes (P < .001). Using a newly derived index, the minimum pachymetry divided by the I-S value (pachymetry/asymmetry [PA]/I-S index) with a cut-off of 100, 100% of early and forme fruste keratoconus could be identified as being abnormal with 7 normals misclassified (misclassification rate 2.7%). By adding keratoconus suspect to the analysis and an I-S value of 1.2 as a cut-off point, 5 suspects were classified as normal and 11 normals as abnormal (misclassification rate 7.8%). the PA/I-S index, with a cut-off point of 100, reduced this misclassification rate to 4.4%.CONCLUSIONS: These results suggest that OCT combined with videokeratography may be more useful for differentiating mild forms of keratoconus than videokeratography alone.
Language English
Sponsor National Eye Institutes of Health
Skirball Foundation for Molecular Ophthalmology, Los Angeles, California
Eye Defects Research Foundation Inc., Beverly Hills, California
Grant number National Eye Institutes of Health: NEI-RO1-09052
Date 2014-02-01
Published in Journal of Refractive Surgery. Thorofare: Slack Inc, v. 30, n. 2, p. 80-+, 2014.
ISSN 1081-597X (Sherpa/Romeo, impact factor)
Publisher Slack Inc
Extent 80-+
Origin http://dx.doi.org/10.3928/1081597X-20140120-02
Access rights Closed access
Type Article
Web of Science ID WOS:000331909400002
URI http://repositorio.unifesp.br/handle/11600/37424

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