Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30

Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30

Author Cramarossa, Gemma Google Scholar
Zeng, Liang Google Scholar
Zhang, Liying Google Scholar
Tseng, Ling-Ming Google Scholar
Hou, Ming-Feng Google Scholar
Fairchild, Alysa Google Scholar
Vassiliou, Vassilios Google Scholar
Jesus-Garcia, Reynaldo Autor UNIFESP Google Scholar
El-Din, Mohamed A. Alm Google Scholar
Kumar, Aswin Google Scholar
Forges, Fabien Google Scholar
Chie, Wei-Chu Google Scholar
Sahgal, Arjun Google Scholar
Lam, Henry Google Scholar
Pulenzas, Natalie Google Scholar
Chow, Edward Google Scholar
Institution Univ Toronto
Natl Yang Ming Univ
Kaohsiung Med Univ Hosp
Cross Canc Inst
Bank Cyprus
Universidade Federal de São Paulo (UNIFESP)
Tanta Univ Hosp
Reg Canc Ctr
St Etienne Univ Hosp
Natl Taiwan Univ
Abstract Objective: To identify which domains/symptoms from the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were predictive of overall quality of life (QoL) in advanced cancer patients. Methods: Four hundred and forty seven patients with brain metastases or bone metastases from seven countries were enrolled with regression analysis to determine the predictive value of the QLQ-C30 functional/symptom scores for patient reported overall QoL (question 30), overall health (question 29) and the global health status domain (questions 29 and 30). Results: Worse role functioning, social functioning, fatigue and financial problems were the most significant predictive factors for worse QoL. in the bone metastases subgroup (n = 400), role functioning, fatigue and financial problems were the most significant predictors. in patients with brain metastases (n = 47), none of the EORTC domains significantly predicted worse QOL. Conclusion: Deterioration of certain QLQ-C30 functional/symptom scores significantly contributes to worse QoL, overall health and global health status.
Keywords advanced cancer
EORTC QLQ-C30
metastatic cancer
quality of life
symptom control
Language English
Sponsor Bratty Family Fund
Michael and Karyn Goldstein Cancer Research Fund
Joseph and Silvana Melara Cancer Research Fund
Ofelia Cancer Research Fund
Date 2014-02-01
Published in Expert Review of Pharmacoeconomics & Outcomes Research. London: Expert Reviews, v. 14, n. 1, p. 139-146, 2014.
ISSN 1473-7167 (Sherpa/Romeo, impact factor)
Publisher Expert Reviews
Extent 139-146
Origin http://dx.doi.org/10.1586/14737167.2014.864560
Access rights Closed access
Type Article
Web of Science ID WOS:000336258600015
URI http://repositorio.unifesp.br/handle/11600/37420

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