Reproductive Function of the Male Obese Zucker Rats: Alteration in Sperm Production and Sperm DNA Damage

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dc.contributor.author Vendramini, V. [UNIFESP]
dc.contributor.author Cedenho, A. P. [UNIFESP]
dc.contributor.author Miraglia, S. M. [UNIFESP]
dc.contributor.author Spaine, D. M. [UNIFESP]
dc.date.accessioned 2016-01-24T14:35:17Z
dc.date.available 2016-01-24T14:35:17Z
dc.date.issued 2014-02-01
dc.identifier http://dx.doi.org/10.1177/1933719113493511
dc.identifier.citation Reproductive Sciences. Thousand Oaks: Sage Publications Inc, v. 21, n. 2, p. 221-229, 2014.
dc.identifier.issn 1933-7191
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37417
dc.description.abstract Obesity has been considered a public health issue in many countries and is of increasing concern for authorities over the past 6 years. the Zucker rat is a good experimental model for obesity and diabetes studies due to its metabolic characteristics that are similar to those developed by humans. A total of 12 obese Zucker rats and their lean littermates were killed in pubertal and young adult phases for assessing organ weights (testis and epididymis), testicular histomorphometric and stereological analyses, daily sperm production, and transit time in the epididymis. Sperm integrity was also investigated in the adult animals using the Comet assay. Alterations in organ weights, seminiferous epithelium architecture, sperm production, and transit time were noticed in the pubertal fatty rats. the volume density of the lymphatic space was decreased in both the ages. Adult animals had a significant increase in the extent of damage found in sperm DNA. Our results show for the first time that leptin receptor deficiency compromises sperm production during puberty and that genetic obese Zucker rats have increased sperm DNA fragmentation. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Division of Urology
dc.description.sponsorship Discipline of Developmental Biology laboratory at UNIFESP
dc.format.extent 221-229
dc.language.iso eng
dc.publisher Sage Publications Inc
dc.relation.ispartof Reproductive Sciences
dc.rights Acesso restrito
dc.subject Zucker rat en
dc.subject obesity en
dc.subject spermatogenesis en
dc.subject sperm production en
dc.subject DNA fragmentation en
dc.title Reproductive Function of the Male Obese Zucker Rats: Alteration in Sperm Production and Sperm DNA Damage en
dc.type Artigo
dc.rights.license http://www.uk.sagepub.com/aboutus/openaccess.htm
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dept Surg, Div Urol, BR-04023900 São Paulo, Brazil
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dev Biol Lab, Dept Morphol & Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dept Surg, Div Urol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dev Biol Lab, Dept Morphol & Genet, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1177/1933719113493511
dc.description.source Web of Science
dc.identifier.wos WOS:000329197700009



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