Ability of vitamin D to reduce inflammation in adults without acute illness

Ability of vitamin D to reduce inflammation in adults without acute illness

Author Zanetti, Mayra Autor UNIFESP Google Scholar
Harris, Susan S. Google Scholar
Dawson-Hughes, Bess Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Tufts Univ
Abstract In vitro studies and some clinical studies suggest that vitamin D plays an important role in reducing inflammation. the objective of this review was to examine recent evidence that vitamin D status influences the level of inflammation in adults without acute illness or injury. Five large cross-sectional studies and two randomized controlled trials are the focus of this review. Associations between 25-hydroxyvitamin D (25OHD) and inflammation markers are significant and inverse in study populations with low 25OHD levels (<21ng/mL). They are also inverse in adults with relatively high inflammation levels. These associations in the few available randomized controlled vitamin D intervention trials have been null; this may be because they were not examined in populations with sufficiently low levels of 25OHD or high levels of inflammation. (C) 2013 International Life Sciences Institute
Keywords 25-hydroxyvitamin D
C-reactive protein
inflammation
vitamin D
Language English
Sponsor U.S. Department of Agriculture
Grant number U.S. Department of Agriculture: 58-1950-0-014
Date 2014-02-01
Published in Nutrition Reviews. Hoboken: Wiley-Blackwell, v. 72, n. 2, p. 95-98, 2014.
ISSN 0029-6643 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 95-98
Origin http://dx.doi.org/10.1111/nure.12095
Access rights Closed access
Type Review
Web of Science ID WOS:000330754500004
URI http://repositorio.unifesp.br/handle/11600/37415

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