Comparison of idiopathic achalasia and Chagas' disease esophagopathy at the light of high-resolution manometry

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dc.contributor.author Vicentine, F. P. P. [UNIFESP]
dc.contributor.author Herbella, F. A. M. [UNIFESP]
dc.contributor.author Allaix, M. E.
dc.contributor.author Silva, L. C. [UNIFESP]
dc.contributor.author Patti, M. G.
dc.date.accessioned 2016-01-24T14:35:17Z
dc.date.available 2016-01-24T14:35:17Z
dc.date.issued 2014-02-01
dc.identifier http://dx.doi.org/10.1111/dote.12098
dc.identifier.citation Diseases of the Esophagus. Hoboken: Wiley-Blackwell, v. 27, n. 2, p. 128-133, 2014.
dc.identifier.issn 1120-8694
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37413
dc.description.abstract The comparison between idiopathic achalasia (IA) and Chagas' disease esophagopathy (CDE) may evaluate if treatment options and their outcomes can be accepted universally. This study aims to compare IA and CDE at the light of high-resolution manometry. We studied 86 patients with achalasia: 45 patients with CDE (54% females, mean age 55 years) and 41 patients with IA (58% females, mean age 49 years). All patients underwent high-resolution manometry. Upper esophageal sphincter parameters were similar (basal pressure CDE = 72 +/- 45mmHg, IA = 82 +/- 57mmHg; residual pressure CDE = 9.9 +/- 9.9mmHg, IA = 9.8 +/- 7.5mmHg). in the body of the esophagus, the amplitude was higher in the IA group than the CDE group at 3cm (CDE = 15 +/- 14mm Hg, IA = 42 +/- 52mmHg, P = 0.003) and 7cm (CDE = 16 +/- 15mmHg, IA = 36 +/- 57mmHg, P = 0.04) above the lower esophageal sphincter (LES). the LES basal pressure (CDE = 17 +/- 16mmHg, IA = 40 +/- 22mmHg, P < 0.001) and residual pressure (CDE = 12 +/- 11mmHg, IA = 27 +/- 13mmHg, P < 0.001) were also higher in the IA group. Our results show that: (i) there is no difference in regards to the upper esophageal sphincter; (ii) higher pressures of the esophageal body are noticed in patients with IA; and (iii) basal and residual pressures of the LES are lower in patients with CDE. Our results did not show expressive manometric differences between IA and CDE. Some differences may be attributed to a more pronounced esophageal dilatation in patients with CDE. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 128-133
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Diseases of the Esophagus
dc.rights Acesso restrito
dc.subject Chagas' disease en
dc.subject esophageal achalasia en
dc.subject manometry en
dc.title Comparison of idiopathic achalasia and Chagas' disease esophagopathy at the light of high-resolution manometry en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Chicago
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Surg, São Paulo, Brazil
dc.description.affiliation Univ Chicago, Dept Surg, Chicago, IL 60637 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Surg, São Paulo, Brazil
dc.identifier.doi 10.1111/dote.12098
dc.description.source Web of Science
dc.identifier.wos WOS:000331129500006



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