Late-onset obsessive-compulsive disorder: Risk factors and correlates

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dc.contributor.author Frydman, Ilana
dc.contributor.author Brasil, Pedro E. do
dc.contributor.author Torres, Albina R.
dc.contributor.author Shavitt, Roseli G.
dc.contributor.author Ferrao, Ygor A.
dc.contributor.author Rosario, Maria C. [UNIFESP]
dc.contributor.author Miguel, Euripedes C.
dc.contributor.author Fontenelle, Leonardo F.
dc.date.accessioned 2016-01-24T14:35:14Z
dc.date.available 2016-01-24T14:35:14Z
dc.date.issued 2014-02-01
dc.identifier http://dx.doi.org/10.1016/j.jpsychires.2013.10.021
dc.identifier.citation Journal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 49, p. 68-74, 2014.
dc.identifier.issn 0022-3956
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37377
dc.description.abstract Background: While a great amount of attention has been paid to early-onset obsessive-compulsive disorder (OCD), there is a dearth of studies on patients showing OCD for the first time at later stages of life. in this study, we aimed at determining possible risk factors/correlates for OCD onset at or after age 40, here termed late-onset OCD.Method: A series of models including several potential variables associated with late onset OCD were tested using a monolayer neural network. To this regard, data from the Brazilian Research Consortium of Obsessive-Compulsive Spectrum Disorders (CTOC) (n = 1001) was employed. for the purposes of this study, we considered a diagnosis of late onset OCD to be present whenever distress and interference associated with OCD symptoms emerged at or after age 40. Different nested models were compared through the Akaike Criteria keeping the variables with p value <= 0.05.Results: Late-onset OCD occurred in 8.6% of the sample. A model including female sex, a history of chronic (>10 years) subclinical obsessive-compulsive symptoms, the co-occurrence of posttraumatic stress disorder (PTSD) after age 40, and a history of recent pregnancy in self or significant others was able to explain a sizeable proportion of late-onset OCD. the general performance of this model, represented by the Maximum Likelihood R2, was 29.4%.Conclusion: Our results suggest that late-onset OCD is more likely to occur in females, in individuals with long periods of subclinical obsessive-compulsive symptoms, and in association with a major traumatic event occurring after age 40 and a history of recent pregnancy in self or in significant others. (C) 2013 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 68-74
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Journal of Psychiatric Research
dc.rights Acesso restrito
dc.subject Obsessive-compulsive disorder en
dc.subject Clinical course en
dc.subject Onset en
dc.subject Late-onset en
dc.subject Phenotype en
dc.title Late-onset obsessive-compulsive disorder: Risk factors and correlates en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institution DOr Inst Res & Educ
dc.contributor.institution Univ Estadual Paulista
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Hlth Sci Fed Univ Porto Alegre
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal Fluminense (UFF)
dc.description.affiliation Univ Fed Rio de Janeiro, Inst Psychiat, Anxiety & Depress Res Program, BR-22640102 Rio de Janeiro, RJ, Brazil
dc.description.affiliation DOr Inst Res & Educ, Rio de Janeiro, Brazil
dc.description.affiliation Univ Estadual Paulista, Botucatu Med Sch, Dept Neurol Psychol & Psychiat, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Dept Psychiat, BR-05508 São Paulo, Brazil
dc.description.affiliation Hlth Sci Fed Univ Porto Alegre, Dept Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliation Univ Fed Fluminense, Inst Community Hlth, Dept Psychiat & Mental Hlth, BR-24220000 Niteroi, RJ, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.sponsorshipID CNPq: CNPq 420.122/2005-2
dc.identifier.doi 10.1016/j.jpsychires.2013.10.021
dc.description.source Web of Science
dc.identifier.wos WOS:000329772800010



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