Brain-Penetrating Angiotensin-Converting Enzyme Inhibitors and Cognitive Change in Patients with Dementia due to Alzheimer's Disease

Brain-Penetrating Angiotensin-Converting Enzyme Inhibitors and Cognitive Change in Patients with Dementia due to Alzheimer's Disease

Author Oliveira, Fabricio Ferreira de Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Chen, Elizabeth Suchi Autor UNIFESP Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Controversy over benefits of angiotensin-converting enzyme inhibitors (ACEIs) for treatment of dementia due to Alzheimer's disease (AD) led to this alternative investigational approach by the employment of pharmacogenetic methods, correlating the cognitive change of patients with late-onset AD with the presence of common ACE gene promoter polymorphisms, and stratifying the sample in groups of patients who responded or not to the brain-penetrating ACEIs Captopril or Perindopril. A trend was found for treatment with brain-penetrating ACEIs to slow cognitive decline in AD patients with the haplotype rs1800764 (CC): rs4291 (TT) (p = 0.024), and also non-significantly for independent carriers of rs1800764 or rs4291.
Keywords Alzheimer's disease
dementia
drug therapy
neurodegenerative diseases
neuropsychiatry
pharmacogenetics
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Behavioral Neurology Section of Hospital São Paulo
Laboratory of Genetics of the Federal University of São Paulo (UNIFESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2014-01-01
Published in Journal of Alzheimers Disease. Amsterdam: Ios Press, v. 42, p. S321-S324, 2014.
ISSN 1387-2877 (Sherpa/Romeo, impact factor)
Publisher Ios Press
Extent S321-S324
Origin http://dx.doi.org/10.3233/JAD-132189
Access rights Closed access
Type Article
Web of Science ID WOS:000341595800034
URI http://repositorio.unifesp.br/handle/11600/37300

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