Maternal Immune Activation Increases the Corticosterone Response to Acute Stress without Affecting the Hypothalamic Monoamine Content and Sleep Patterns in Male Mice Offspring

Maternal Immune Activation Increases the Corticosterone Response to Acute Stress without Affecting the Hypothalamic Monoamine Content and Sleep Patterns in Male Mice Offspring

Author Zager, Adriano Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Palermo-Neto, Joao Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background/Aims: Early life experiences are homeostatic determinants for adult organisms. We evaluated the impact of prenatal immune activation during late gestation on the neuroimmune-endocrine function of adult offspring and its interaction with acute stress. Methods: Pregnant Swiss mice received saline or lipopolysaccharide (LPS) on gestational day 17. Adult male offspring were assigned to the control or restraint stress condition. We analyzed plasmatic corticosterone and catecholamine levels, the monoamine content in the hypothalamus, striatum and frontal cortex, and the sleep-wake cycle before and after acute restraint stress. Results and Conclusion:Offspring from LPS-treated dams had increased baseline norepinephrine levels and potentiated corticosterone secretion after the acute stressor, and no effect was observed on hypothalamic monoamine content or sleep behavior. the offspring of immune-activated dams exhibited impairments in stress-induced serotonergic and dopaminergic alterations in the striatum and frontal cortex. the data demonstrate a distinction between the plasmatic levels of corticosterone in response to acute stress and the hypothalamic monoamine content and sleep patterns. We provide new evidence regarding the influence of immune activation during late gestation on the neuroendocrine homeostasis of offspring. (C) 2013 S. Karger AG, Basel
Keywords Prenatal lipopolysaccharide
Hypothalamic-pituitary-adrenal axis
Sympathoadrenal system
Corticosterone
Norepinephrine
Monoamine content
Sleep patterns
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 09/51886-3
FAPESP: 09/51998-6
FAPESP: 98/14303
Date 2014-01-01
Published in Neuroimmunomodulation. Basel: Karger, v. 21, n. 1, p. 37-44, 2014.
ISSN 1021-7401 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 37-44
Origin http://dx.doi.org/10.1159/000355466
Access rights Closed access
Type Article
Web of Science ID WOS:000327922500006
URI http://repositorio.unifesp.br/handle/11600/37286

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