Genetic Association Study of Angiotensin II Receptor Types 1 (A168G) and 2 (T1247G and A5235G) Polymorphisms in Breast Carcinoma among Brazilian Women

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dc.contributor.author Wolgien, Maria del Carmen Molina [UNIFESP]
dc.contributor.author Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
dc.contributor.author Nazário, Afonso Celso Pinto [UNIFESP]
dc.contributor.author Nakaie, Clovis Ryuichi [UNIFESP]
dc.contributor.author Corrêa, Silvana Aparecida Alves [UNIFESP]
dc.contributor.author Noronha, Samuel Marcos Ribeiro de [UNIFESP]
dc.contributor.author Facina, Gil [UNIFESP]
dc.date.accessioned 2016-01-24T14:35:01Z
dc.date.available 2016-01-24T14:35:01Z
dc.date.issued 2014-01-01
dc.identifier http://dx.doi.org/10.1159/000363429
dc.identifier.citation Breast Care. Basel: Karger, v. 9, n. 3, p. 176-181, 2014.
dc.identifier.issn 1661-3791
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37210
dc.description.abstract Background: Many types of cancer are associated with polymorphisms of the renin-angiotensin system. Our aim was to assess possible association between single-nucleotide polymorphisms (SNPs) of the angiotensin II receptor types 1 (A168G), and 2 (T1247G and A5235G) with breast cancer. Patients and Methods: 242 participating subjects were genotyped and allocated to case or control groups. Results: Genotype distribution (in %) was: for AGTR1 (A168G): AA, AG, GG = 61, 30, 09 for cases, and 69, 25, 06 for controls (p = 0.55); for AGTR2 (T1247G): TT, TG, GG = 84, 12, 04 for cases, and 81, 17, 02 for controls (p = 0.45); for AGTR2 (A5235G): AA, AG, GG = 32, 67, 01 for cases, and 53, 28, 19 for controls (p < 0.0001). Women carrying genotypes AA/AG in the intronic region of angiotensin II type 2 receptor had an 11-fold higher risk of breast cancer than GG carriers. Conclusions: Many types of cancer have been associated with polymorphisms of the renin-angiotensin system. for SNP A5235G, the GG genotype seems to be protective against breast cancer. the other 2 SNPs showed no association. However, SNPs T1247G and A5235G were associated with at least 1 clinical variable, with G being a predictor of better outcome. the use of SNPs A5235G and T1247G (the latter to a lesser degree) as genetic markers should be considered. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 176-181
dc.language.iso eng
dc.publisher Karger
dc.relation.ispartof Breast Care
dc.rights Acesso aberto
dc.subject Angiotensin II type 1 receptor en
dc.subject Angiotensin II type 2 receptor en
dc.subject Breast neoplasm en
dc.subject Genetic polymorphisms en
dc.subject Genotyping en
dc.title Genetic Association Study of Angiotensin II Receptor Types 1 (A168G) and 2 (T1247G and A5235G) Polymorphisms in Breast Carcinoma among Brazilian Women en
dc.type Artigo
dc.rights.license http://www.karger.com/Services/RightsPermissions
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo EPM UNIFESP, Escola Paulista Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo EPM UNIFESP, Escola Paulista Med, Dept Biophys, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo EPM UNIFESP, Escola Paulista Med, Dept Surg, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo EPM UNIFESP, Escola Paulista Med, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo EPM UNIFESP, Escola Paulista Med, Dept Biophys, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo EPM UNIFESP, Escola Paulista Med, Dept Surg, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2007/56480-0
dc.description.sponsorshipID FAPESP: 2008/50776-7
dc.description.sponsorshipID FAPESP: 2008/54383-0
dc.identifier.doi 10.1159/000363429
dc.description.source Web of Science
dc.identifier.wos WOS:000339142100005



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