Genetic Association Study of Angiotensin II Receptor Types 1 (A168G) and 2 (T1247G and A5235G) Polymorphisms in Breast Carcinoma among Brazilian Women

Genetic Association Study of Angiotensin II Receptor Types 1 (A168G) and 2 (T1247G and A5235G) Polymorphisms in Breast Carcinoma among Brazilian Women

Author Wolgien, Maria del Carmen Molina Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Nazário, Afonso Celso Pinto Autor UNIFESP Google Scholar
Nakaie, Clovis Ryuichi Autor UNIFESP Google Scholar
Corrêa, Silvana Aparecida Alves Autor UNIFESP Google Scholar
Noronha, Samuel Marcos Ribeiro de Autor UNIFESP Google Scholar
Facina, Gil Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Many types of cancer are associated with polymorphisms of the renin-angiotensin system. Our aim was to assess possible association between single-nucleotide polymorphisms (SNPs) of the angiotensin II receptor types 1 (A168G), and 2 (T1247G and A5235G) with breast cancer. Patients and Methods: 242 participating subjects were genotyped and allocated to case or control groups. Results: Genotype distribution (in %) was: for AGTR1 (A168G): AA, AG, GG = 61, 30, 09 for cases, and 69, 25, 06 for controls (p = 0.55); for AGTR2 (T1247G): TT, TG, GG = 84, 12, 04 for cases, and 81, 17, 02 for controls (p = 0.45); for AGTR2 (A5235G): AA, AG, GG = 32, 67, 01 for cases, and 53, 28, 19 for controls (p < 0.0001). Women carrying genotypes AA/AG in the intronic region of angiotensin II type 2 receptor had an 11-fold higher risk of breast cancer than GG carriers. Conclusions: Many types of cancer have been associated with polymorphisms of the renin-angiotensin system. for SNP A5235G, the GG genotype seems to be protective against breast cancer. the other 2 SNPs showed no association. However, SNPs T1247G and A5235G were associated with at least 1 clinical variable, with G being a predictor of better outcome. the use of SNPs A5235G and T1247G (the latter to a lesser degree) as genetic markers should be considered.
Keywords Angiotensin II type 1 receptor
Angiotensin II type 2 receptor
Breast neoplasm
Genetic polymorphisms
Genotyping
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2007/56480-0
FAPESP: 2008/50776-7
FAPESP: 2008/54383-0
Date 2014-01-01
Published in Breast Care. Basel: Karger, v. 9, n. 3, p. 176-181, 2014.
ISSN 1661-3791 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 176-181
Origin http://dx.doi.org/10.1159/000363429
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000339142100005
URI http://repositorio.unifesp.br/handle/11600/37210

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