Impact of Radial and Partial Nephrectomy on Rental Function in Patients with Renal Cancer

Impact of Radial and Partial Nephrectomy on Rental Function in Patients with Renal Cancer

Author Krebs, Rodrigo Ketzer Autor UNIFESP Google Scholar
Andreoni, Cássio Autor UNIFESP Google Scholar
Ortiz, Valdemar Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To evaluate renal function in renal cancer patients undergoing radical nephrectomy (RN) or partial nephrectomy (PN) (open or laparoscopic ORN, OPN, LRN or LPN) and to identify risk factors contributing to renal function loss. Methods: We analysed 228 consecutive renal cancer patients admitted for OPN, LPN, ORN or LRN. the variables analysed were age, gender, weight, type of surgery (radical versus partial), type of surgical access (open versus laparoscopic), preoperative renal function and history of hypertension, diabetes or malignancy. Absolute renal function was calculated as the difference in glomerular filtration rate (AGFR) between the renal function before (GFR(0)) and 12 months after surgery (GFR(12)). the relative renal function of patients undergoing PN and RN was evaluated by the change in chronic kidney disease stage. Results: LRN caused the greatest loss in absolute renal function, followed by ORN, LPN and OPN. A GFR of >= 60 ml/min was noted for 90(68.7%) patients before and 65 (49.6%) patients after RN and for 80 (82.5%) patients before and 74 (76.3%) patients after PN. the chronic kidney disease stage dropped to 4 or 5 in the case preoperative weight and type of surgery (radical versus partial) had a significant impact on renal function. Conclusion: Renal function significantly decreased in patients undergoing RN, irrespective of the access route. Patients With preoperative poor renal function are at risk of postoperative end-stage renal disease. (c) 2014 S. Karger AG, Basel
Keywords Renal cancer
Renal function
Chronic renal disease
Partial nephrectonny
Radical nephrectomy
Language English
Date 2014-01-01
Published in Urologia Internationalis. Basel: Karger, v. 92, n. 4, p. 449-454, 2014.
ISSN 0042-1138 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 449-454
Origin http://dx.doi.org/10.1159/000355609
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000336947700013
URI http://repositorio.unifesp.br/handle/11600/37207

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