Chagas Disease: Still Many Unsolved Issues

Chagas Disease: Still Many Unsolved Issues

Author Alvarez, Jose M. Google Scholar
Fonseca, Raissa Google Scholar
Silva, Henrique Borges da Google Scholar
Marinho, Claudio R. F. Google Scholar
Bortoluci, Karina R. Autor UNIFESP Google Scholar
Sardinha, Luiz R. Google Scholar
Epiphanio, Sabrina Google Scholar
D'Imperio Lima, Maria Regina Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Abstract Over the past 20 years, the immune effector mechanisms involved in the control of Trypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described. However, the main questions on the physiopathology of Chagas disease remain unanswered: Why does the host immune system fail to provide sterile immunity? and Why do only a proportion of infected individuals develop chronic pathology? in this review, we describe the mechanisms proposed to explain the inability of the immune system to eradicate the parasite and the elements that allow the development of chronic heart disease. Moreover, we discuss the possibility that the inability of infected cardiomyocytes to sense intracellular T. cruzi contributes to parasite persistence in the heart and the development of chronic pathology.
Language English
Grant number FAPESP: 2013/08199-0
CNPq: 303269/2010-3
Date 2014-01-01
Published in Mediators of Inflammation. New York: Hindawi Publishing Corporation, 9 p., 2014.
ISSN 0962-9351 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 9
Origin http://dx.doi.org/10.1155/2014/912965
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000338869500001
URI http://repositorio.unifesp.br/handle/11600/37162

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