Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese Mice

Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese Mice

Author Morais Honorato de Souza, Gabriel Inacio de Autor UNIFESP Google Scholar
Santamarina, Aline Boveto Autor UNIFESP Google Scholar
Santana, Aline Alves de Autor UNIFESP Google Scholar
Lira, Fabio Santos Google Scholar
laquila, Rachel de Google Scholar
Moreno, Mayara Franzoi Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Penha Oller do Nascimento, Claudia Maria da Autor UNIFESP Google Scholar
Rodrigues, Bruno Google Scholar
Esposito, Elisa Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Sao Judas Tadeu
Univ Estadual Paulista
FAINC
Abstract Functional foods containing bioactive compounds of whey may play an important role in prevention and treatment of obesity. the aim of this study was to investigate the prospects of the biotechnological process of coacervation of whey proteins (CWP) in chitosan and test its antiobesogenic potential. Methods. CWP (100mg.kg.day) was administered in mice with diet-induced obesity for 8 weeks. the animals were divided into four groups: control normocaloric diet gavage with water (C) or coacervate (C-CWP), and high fat diet gavage with water (HF) or coacervate (HF-CWP). Results. HF-CWP reduced weight gain and serum lipid fractions and displayed reduced adiposity and insulin. Adiponectin was significantly higher in HF-CWP group when compared to the HF. the level of LPS in HF-W group was significantly higher when compared to HF-CWP. the IL-10 showed an inverse correlation between the levels of insulin and glucose in the mesenteric adipose tissue in the HF-CWP group. CWP promoted an increase in both phosphorylation AMPK and the amount of ATGL in the mesenteric adipose tissue in HF-CWP group. Conclusion. CWP was able to modulate effects, possibly due to its high biological value of proteins. We observed a protective effect against obesity and improved the inflammatory milieu of white adipose tissue.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 2009/53801-5
Date 2014-01-01
Published in Mediators of Inflammation. New York: Hindawi Publishing Corporation, 13 p., 2014.
ISSN 0962-9351 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 13
Origin http://dx.doi.org/10.1155/2014/281097
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000344254700001
URI http://repositorio.unifesp.br/handle/11600/37132

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