Adipokines during early abstinence of crack cocaine in dependent women reporting childhood maltreatment

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dc.contributor.author Levandowski, Mateus L.
dc.contributor.author Viola, Thiago W.
dc.contributor.author Tractenberg, Saulo G.
dc.contributor.author Teixeira, Antonio L.
dc.contributor.author Brietzke, Elisa [UNIFESP]
dc.contributor.author Bauer, Moises E.
dc.contributor.author Grassi-Oliveira, Rodrigo
dc.date.accessioned 2016-01-24T14:34:52Z
dc.date.available 2016-01-24T14:34:52Z
dc.date.issued 2013-12-15
dc.identifier http://dx.doi.org/10.1016/j.psychres.2013.07.007
dc.identifier.citation Psychiatry Research. Clare: Elsevier B.V., v. 210, n. 2, p. 536-540, 2013.
dc.identifier.issn 0165-1781
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/37084
dc.description.abstract Childhood maltreatment has been associated with addiction and immune dysregulation, although neurobiological substrates underlying this association remain largely unknown. the aim of the study was to compare plasma levels of adipokines during early abstinence in crack cocaine dependent women with (CM+) and without history of childhood maltreatment (CM). One hundred four crack cocaine female users were followed for 20 days in a detoxification inpatient treatment unit. Plasma levels of adiponectin, resistin and leptin were assessed every 7 days during 3 weeks of follow-up. the Childhood Trauma Questionnaire (CTQ) retrospectively assessed childhood maltreatment history. A healthy control group was included to provide adipokines reference values (HC). All crack users increased leptin plasma levels during early abstinence despite concentrations remained lower in comparison with non-users group. Crack users reporting childhood maltreatment exhibited a significant reduction in plasma levels of adiponectin and resistin when compared to CM group. in addition, only CM participants increased plasma levels of adiponectin during detoxification. This is the first study evaluating adipokines during crack cocaine abstinence. Our results suggest a modulator effect of childhood maltreatment on inflammatory status in treatment-seeking crack cocaine dependents during early abstinence. (C) 2013 Elsevier Ireland Ltd. All rights reserved. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship MCT/CT-Saude
dc.description.sponsorship DECIT/SCTIE/MS
dc.description.sponsorship FAPERGS
dc.format.extent 536-540
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Psychiatry Research
dc.rights Acesso restrito
dc.subject Substance-related disorders en
dc.subject Adiponectin en
dc.subject Leptin en
dc.subject Inflammation en
dc.subject Child abuse en
dc.subject Immune system en
dc.subject Follow-up study en
dc.title Adipokines during early abstinence of crack cocaine in dependent women reporting childhood maltreatment en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Pontificia Univ Catolica Rio Grande do Sul
dc.contributor.institution Universidade Federal de Minas Gerais (UFMG)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Pontificia Univ Catolica Rio Grande do Sul, Ctr Studies & Res Traumat Stress, BR-90619900 Porto Alegre, RS, Brazil
dc.description.affiliation Univ Fed Minas Gerais, Neurosci Program, BR-30130100 Belo Horizonte, MG, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Interdisciplinary Lab Clin Neurosci, BR-04044000 São Paulo, Brazil
dc.description.affiliation Pontificia Univ Catolica Rio Grande do Sul, Inst Biomed Res, Lab Immunosenescence, BR-90619900 Porto Alegre, RS, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Interdisciplinary Lab Clin Neurosci, BR-04044000 São Paulo, Brazil
dc.identifier.doi 10.1016/j.psychres.2013.07.007
dc.description.source Web of Science
dc.identifier.wos WOS:000328518600026



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