Adipokines during early abstinence of crack cocaine in dependent women reporting childhood maltreatment

Adipokines during early abstinence of crack cocaine in dependent women reporting childhood maltreatment

Author Levandowski, Mateus L. Google Scholar
Viola, Thiago W. Google Scholar
Tractenberg, Saulo G. Google Scholar
Teixeira, Antonio L. Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Bauer, Moises E. Google Scholar
Grassi-Oliveira, Rodrigo Google Scholar
Institution Pontificia Univ Catolica Rio Grande do Sul
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Abstract Childhood maltreatment has been associated with addiction and immune dysregulation, although neurobiological substrates underlying this association remain largely unknown. the aim of the study was to compare plasma levels of adipokines during early abstinence in crack cocaine dependent women with (CM+) and without history of childhood maltreatment (CM). One hundred four crack cocaine female users were followed for 20 days in a detoxification inpatient treatment unit. Plasma levels of adiponectin, resistin and leptin were assessed every 7 days during 3 weeks of follow-up. the Childhood Trauma Questionnaire (CTQ) retrospectively assessed childhood maltreatment history. A healthy control group was included to provide adipokines reference values (HC). All crack users increased leptin plasma levels during early abstinence despite concentrations remained lower in comparison with non-users group. Crack users reporting childhood maltreatment exhibited a significant reduction in plasma levels of adiponectin and resistin when compared to CM group. in addition, only CM participants increased plasma levels of adiponectin during detoxification. This is the first study evaluating adipokines during crack cocaine abstinence. Our results suggest a modulator effect of childhood maltreatment on inflammatory status in treatment-seeking crack cocaine dependents during early abstinence. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Keywords Substance-related disorders
Adiponectin
Leptin
Inflammation
Child abuse
Immune system
Follow-up study
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
MCT/CT-Saude
DECIT/SCTIE/MS
FAPERGS
Date 2013-12-15
Published in Psychiatry Research. Clare: Elsevier B.V., v. 210, n. 2, p. 536-540, 2013.
ISSN 0165-1781 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 536-540
Origin http://dx.doi.org/10.1016/j.psychres.2013.07.007
Access rights Closed access
Type Article
Web of Science ID WOS:000328518600026
URI http://repositorio.unifesp.br/handle/11600/37084

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