Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax

Comparative recognition by human IgG antibodies of recombinant proteins representing three asexual erythrocytic stage vaccine candidates of Plasmodium vivax

Autor Barbedo, Mayara B Google Scholar
Ricci, Ricardo Google Scholar
Jimenez, Maria Carolina S Google Scholar
Cunha, Maristela G Google Scholar
Yazdani, Syed S Google Scholar
Chitnis, Chetan E Google Scholar
Rodrigues, Mauricio Martins Autor UNIFESP Google Scholar
Soares, Irene S Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal do Pará Centro de Ciências Biológicas Departamento de Patologia
International Centre for Genetic Engineering and Biotechnology Centro de Ciências Biológicas Malaria Research Group
Universidade Federal de São Paulo (UNIFESP)
Resumo In previous immuno-epidemiological studies of the naturally acquired antibody responses to merozoite surface protein-1 (MSP-1) of Plasmodium vivax, we had evidence that the responses to distinct erythrocytic stage antigens could be differentially regulated. The present study was designed to compare the antibody response to three asexual erythrocytic stage antigens vaccine candidates of P. vivax. Recombinant proteins representing the 19 kDa C-terminal region of MSP-1(PvMSP19), apical membrane antigen n-1 ectodomain (PvAMA-1), and the region II of duffy binding protein (PvDBP-RII) were compared in their ability to bind to IgG antibodies of serum samples collected from 220 individuals from the state of Pará, in the North of Brazil. During patent infection with P. vivax, the frequency of individuals with IgG antibodies to PvMSP1(19), PvAMA-1, and PvDBP-RII were 95, 72.7, and 44.5% respectively. Although the frequency of responders to PvDBP-RII was lower, this frequency increased in individuals following multiple malarial infections. Individually, the specific antibody levels did not decline significantly nine months after treatment, except to PvMSP1(19). Our results further confirm a complex regulation of the immune response to distinct blood stage antigens. The reason for that is presently unknown but it may contribute to the high risk of re-infection in individuals living in the endemic areas.
Palavra-chave malaria
Plasmodium vivax
merozoite antigens
IgG antibody response
Idioma Inglês
Data de publicação 2007-06-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 102, n. 3, p. 335-340, 2007.
ISSN 0074-0276 (Sherpa/Romeo)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 335-340
Fonte http://dx.doi.org/10.1590/S0074-02762007005000040
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0074-02762007000300013 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/3705

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