Attention impairment associated with relapsing-remitting multiple sclerosis patients with mild incapacity

Attention impairment associated with relapsing-remitting multiple sclerosis patients with mild incapacity

Alternative title Prejuízo da atenção em pacientes com esclerose múltipla na forma remitente-recorrente com incapacidade leve
Author Balsimelli, Silvia Google Scholar
Mendes, Maria Fernanda Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Tilbery, Charles Peter Google Scholar
Institution Santa Casa School of Medical Sciences Department of Neurology
Universidade Federal de São Paulo (UNIFESP)
Abstract Neuropsychological studies have consistently reported cognitive dysfunctions associated with multiple sclerosis. One-hundred fifteen subjects with relapsing-remitting multiple sclerosis (RRMS) were compared with forty health controls according to a neuropsychological test battery, which included digit span, trail making, cancellation and stroop test. Both groups were matched for age, sex and educational level. Subjects with RRMS had a worse performance the speed of response. Subjects with RRMS spent more time to complete the test in either sections A (p=0.001) or B (p=0.001), although there was no significant difference in terms of number of errors. The total time required to finish the Stroop test was higher for subjects with RRMS (p<0.001), being the time difference between groups significant at trial 4 (p<0.001). Attention impairment in subjects with RRMS is related to slowed central processing, which may be affected in all stages, including impairment of automatic and controlled processing of information and in the motor program.

Estudos neuropsicológicos demonstram alterações cognitivas associadas à esclerose múltipla. Foram avaliados, através de uma bateria neuropsicológica, 115 pacientes com esclerose múltipla remitente-recorrente (EMRR), comparada a um grupo controle com 40 indivíduos saudáveis. A bateria inclui os testes, span de dígitos, trilhas, teste de cancelamento e stroop. Os grupos foram pareados por sexo, idade e escolaridade.Os pacientes com EMRR tiveram um pior desempenho na rapidez de resposta (p=0,001), os pacientes gastaram um tempo maior para realizar o trilhas A (p=0,001) e o trilhas B (p=0,0001), não havendo diferenças significativas no número de erros. O tempo total no teste stroop foi maior dos sujeitos EMRR (p<0,001), apresentando diferença significativa na tentativa 4 (p<0,001). Os pacientes EMRR apresentaram lentificação do processamento central, podendo estar prejudicado em todos os estágios da doença, incluindo prejuízo do processamento de informações automático e controlado.
Keywords multiple sclerosis
cognition
attention
esclerose múltipla
cognição
atenção
Language English
Date 2007-06-01
Published in Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 65, n. 2A, p. 262-267, 2007.
ISSN 0004-282X (Sherpa/Romeo)
Publisher Academia Brasileira de Neurologia - ABNEURO
Extent 262-267
Origin http://dx.doi.org/10.1590/S0004-282X2007000200014
Access rights Open access Open Access
Type Article
SciELO ID S0004-282X2007000200014 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/3703

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