Does low birth weight affect the presence of cardiometabolic risk factors in overweight and obese children?

Does low birth weight affect the presence of cardiometabolic risk factors in overweight and obese children?

Author Ponzio, Caroline Autor UNIFESP Google Scholar
Palomino, Zaira Autor UNIFESP Google Scholar
Puccini, Rosana Fiorini Autor UNIFESP Google Scholar
Strufaldi, Maria Wany L. Autor UNIFESP Google Scholar
Franco, Maria C. P. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Recent findings suggest that low-birth-weight children with current obesity are more likely to have higher systolic blood pressure levels and impaired beta-cell function than those who are obese with normal birth weight. It seems possible, however, that concurrent low birth weight with excess weight gain can exacerbate other risk factors for cardiometabolic diseases. the purpose of this study is to investigate the influence of birth weight on the lipid/apolipoprotein profile, visfatin levels, and insulin parameters in overweight/obese children. A cross-sectional study of 68 overweight/obese children was conducted. Among these children, 28 were identified with low birth weight and 40 were of normal birth weight. Blood lipid profile, apolipoproteins, visfatin, glucose, and insulin were measured. Our results show that systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels, triglycerides (TG), very low-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDLc), apolipoprotein B and E, insulin, apolipoprotein B/A(1) ratio, and homeostasis model assessment insulin resistance (HOMA-IR) were significantly elevated in overweight/obese low-birth-weight (LBW) children. There was a significant association of the SBP levels with TG (P = 0.027), LDLc (P = 0.001), HOMA-IR (P < 0.001), apolipoprotein B (P = 0.001), and apolipoprotein E (P = 0.039). Conclusion: Our findings suggest that LBW children with overweight or obesity have an additional risk factor for both atherogenic and insulinogenic profile.
Keywords Birth weight
Overweight
Obesity
Apolipoprotein
Visfatin
Children
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 07/58044-2
Date 2013-12-01
Published in European Journal of Pediatrics. New York: Springer, v. 172, n. 12, p. 1687-1692, 2013.
ISSN 0340-6199 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1687-1692
Origin http://dx.doi.org/10.1007/s00431-013-2113-5
Access rights Closed access
Type Article
Web of Science ID WOS:000327404800016
URI http://repositorio.unifesp.br/handle/11600/37029

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