Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice

Ginger Essential Oil Ameliorates Cisplatin-Induced Nephrotoxicity in Mice

Author Damiao, Marcio Jose Autor UNIFESP Google Scholar
Giannocco, Gisele Autor UNIFESP Google Scholar
Grespan, Renata Google Scholar
Silva, Expedito Leite Google Scholar
Duarte, Janaina S. Autor UNIFESP Google Scholar
Maciel, Rui Monteiro de Barros Autor UNIFESP Google Scholar
Yamada, Alcileia Nunes Google Scholar
Bersani-Amado, Ciomar Aparecida Google Scholar
Cuman, Roberto Kenji Nakamura Google Scholar
Institution Universidade Estadual de Maringá (UEM)
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: To investigate the effect of ginger essential oil (GEO) in an experimental model of cisplatin-induced nephrotoxicity.Methods: Male mice were divided into treatment six groups (n = 7), namely: Groups I (saline), II and III (cisplatin, 10 mg/kg, i.p.) euthanized in 3th and 6th days, respectively, and IV, V and IV (GEO, 100, 200 and 400 mg/kg/day, respectively, by gavage 3, 4, 5 and 6 days after cisplatin injection). Creatinine levels and protein/creatinine ratio were determined in plasma and urine, respectively. Bone morphogenic protein (BMP-7) and tumor necrosis factor (TNF-alpha) levels of kidney tissues were determined while mRNA expression levels were obtained using real-time polymerase chain reaction.Results: GEO treatment reduced significantly creatinine levels to 0.53 +/- 0.02; 0.48 +/- 0.008 and 0.46 +/- 0.02 at 100, 200 and 400 mg/kg, respectively, compared with control (0.70 +/- 0.01) [p< 0.05] but increased protein : creatinine ratio to 0.21 +/- 0.01, 0.22 +/- 0.01, 0.24 +/- 0.02 compared with control (0.06 +/- 0.008) [p< 0.05]. Pro-inflammatory TNF-alpha mRNA expression was decreased to 1.46 +/- 0.21, 1.39 +/- 0.19 and 1.36 +/- 0.09, at GEO doses of 100, 200 and 400 mg/kg, respectively, while anti-fibrotic BMP-7 mRNA expression increased to 2.05 +/- 0.26 and 2.44 +/- 0.42 at doses of 200 and 400 mg/kg, respectively, compared with control (0.59 +/- 0.39, p < 0.05).Conclusion: GEO treatment attenuates cisplatin-induced nephrotoxicity, in part, by modulating some inflammatory cytokines.
Keywords Zingiber officinale
Ginger
Roscoe
Essential oil
Nephrotoxicity
Cisplatin
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-12-01
Published in Tropical Journal of Pharmaceutical Research. Benin City: Pharmacotherapy Group, v. 12, n. 6, p. 959-965, 2013.
ISSN 1596-5996 (Sherpa/Romeo, impact factor)
Publisher Pharmacotherapy Group
Extent 959-965
Origin http://dx.doi.org/10.4314/tjpr.v12i6.14
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000332072500014
URI http://repositorio.unifesp.br/handle/11600/37024

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