Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels

Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels

Author Bhutani, Vinod K. Google Scholar
Zipursky, Alvin Google Scholar
Blencowe, Hannah Google Scholar
Khanna, Rajesh Google Scholar
Sgro, Michael Google Scholar
Ebbesen, Finn Google Scholar
Bell, Jennifer Google Scholar
Mori, Rintaro Google Scholar
Slusher, Tina M. Google Scholar
Fahmy, Nahed Google Scholar
Paul, Vinod K. Google Scholar
Du, Lizhong Google Scholar
Okolo, Angela A. Google Scholar
Almeida, Maria-Fernanda de Autor UNIFESP Google Scholar
Olusanya, Bolajoko O. Google Scholar
Kumar, Praveen Google Scholar
Cousens, Simon Google Scholar
Lawn, Joy E. Google Scholar
Institution Hosp Sick Children
Stanford Univ
London Sch Hyg & Trop Med
Saving Newborn Lives Save Children
St Michaels Hosp
Aalborg Univ Hosp
Natl Ctr Child Hlth & Dev
Univ Minnesota
Kasr Al Aini Univ
All India Inst Med Sci
Zhejiang Univ
Nigerian Soc Neonatal Med
Universidade Federal de São Paulo (UNIFESP)
Ctr Hlth Start Initiat
Post Grad Inst Med Educ & Res
Abstract BACKGROUND: Rhesus (Rh) disease and extreme hyperbilirubinemia (EHB) result in neonatal mortality and long-term neurodevelopmental impairment, yet there are no estimates of their burden.METHODS: Systematic reviews and meta-analyses were undertaken of national prevalence, mortality, and kernicterus due to Rh disease and EHB. We applied a compartmental model to estimate neonatal survivors and impairment cases for 2010.RESULTS: Twenty-four million (18% of 134 million live births >= 32wk gestational age from 184 countries; uncertainty range: 23-26 million) were at risk for neonatal hyperbilirubinemia-related adverse outcomes. of these, 480,700(0.36%) had either Rh disease (373,300; uncertainty range: 271,800-477,500) or developed EHB from other causes (107,400; uncertainty range: 57,000-131,000), with a 24% risk for death (114,100; uncertainty range: 59,700-172,000), 13% for kernicterus (75,400), and 11% for stillbirths. Three-quarters of mortality occurred in sub-Saharan Africa and South Asia. Kernicterus with Rh disease ranged from 38, 28, 28, and 25/100,000 live births for Eastern Europe/Central Asian, sub-Saharan African, South Asian, and Latin American regions, respectively. More than 83% of survivors with kernicterus had one or more impairments.CONCLUSION: Failure to prevent Rh sensitization and manage neonatal hyperbilirubinemia results in 114,100 avoidable neonatal deaths and many children grow up with disabilities. Proven solutions remain underused, especially in low-income countries.
Language English
Sponsor March of Dimes Prematurity Research Center at Stanford University School of Medicine
Bill and Melinda Gates Foundation
Date 2013-12-01
Published in Pediatric Research. New York: Nature Publishing Group, v. 74, p. 86-100, 2013.
ISSN 0031-3998 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent 86-100
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000331157400007

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