Successful Intra-arterial Thrombolysis in a Patient with an Intracranial Meningioma

Successful Intra-arterial Thrombolysis in a Patient with an Intracranial Meningioma

Autor Baiense, Robson F. Autor UNIFESP Google Scholar
Abrahao, Agessandro Autor UNIFESP Google Scholar
Ricarte, Irapua F. Autor UNIFESP Google Scholar
Fukuda, Thiago G. Autor UNIFESP Google Scholar
Oliveira, Ricardo A. Autor UNIFESP Google Scholar
Silva, Gisele S. Autor UNIFESP Google Scholar
Costa, Maristela Google Scholar
Teixeira, Manoel J. Google Scholar
Instituição Hosp Coracao
Universidade Federal de São Paulo (UNIFESP)
Resumo Alteplase (recombinant tissue plasminogen activator [rt-PA]) label approval by the Food and Drug Administration remarks the contraindication of its use with known intracranial neoplasm because of potential bleeding complications. Despite this concern, the real risk of intracerebral bleeding in patients with intracranial neoplasms treated with rt-PA is unknown, and there are few reports of thrombolysis in patients with brain tumors. We report a case of a 78-year-old man who was seen in our emergency department within 2 hours from sudden onset of aphasia, right-sided hemiplegia, hypoesthesia, and homonymous hemianopsia. the National Institutes of Health Stroke Scale (NIHSS) score at admission was 20. Intra-arterial thrombolysis was performed with administration of .3 mg/kg of alteplase combined with mechanical thrombectomy. At discharge, his NIHSS score was 1, and after 90 days, his modified Rankin score was 1. To our knowledge, this is the first report of intra-arterial thrombolysis in a patient with acute ischemic stroke with an intracranial tumor.
Assunto Intra-arterial thrombolysis
meningioma
intracranial neoplasm
acute ischemic stroke
mechanical thrombectomy
intracranial hemorrhage
Idioma Inglês
Data 2013-11-01
Publicado em Journal of Stroke & Cerebrovascular Diseases. Amsterdam: Elsevier B.V., v. 22, n. 8, p. E658-E660, 2013.
ISSN 1052-3057 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão E658-E660
Fonte http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2013.05.009
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000327719000066
URI http://repositorio.unifesp.br/handle/11600/36946

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