Alpha1-adrenergic drugs affect the development and expression of ethanol-induced behavioral sensitization

Alpha1-adrenergic drugs affect the development and expression of ethanol-induced behavioral sensitization

Autor Kim, Andrezza Kyunmi Autor UNIFESP Google Scholar
Oliveira Souza-Formigoni, Maria Lucia Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Background: According to the incentive sensitization theory, addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic systems. After repeated ethanol administration, some animals develop psychomotor sensitization, a phenomenon which occurs simultaneously with the incentive sensitization. Recent evidence suggests the involvement of norepinephrine (NE) in drug addiction, with a critical role in the ethanol reinforcing properties. in this study we evaluated the influence of an agonist (phenylephrine) and an antagonist (prazosin) of alpha1-adrenergic receptors on the development and expression of behavioral sensitization to ethanol. Male Swiss mice, previously treated with ethanol or saline, were challenged with the combined administration of ethanol (or saline) with alpha1-adrenergic drugs. Prazosin (0.1; 0.5 and 1.0 mg/kg) and phenylephrine (1.0 and 2.0 mg/kg) administration blocked the expression of behavioral sensitization to ethanol. in another set of experiments, mice treated with 0.5 mg/kg of prazosin + ethanol did not present the development of behavioral sensitization. However, when challenged with ethanol alone, they showed the same sensitized levels of locomotor activity of those presented by mice previously treated with ethanol and saline. Phenylephrine (1.0 mg/kg) treatment did not affect the development of behavioral sensitization. Based on this data, we concluded that the alteration of alphal-adrenergic receptors functioning, by the administration agonists or antagonists, affected the locomotor sensitization to the stimulant effect of ethanol, suggesting that the normal functioning of the noradrenergic system is essential to its development and expression. (C) 2013 Elsevier B.V. All rights reserved.
Assunto Ethanol
Prazosin
Phenylephrine
Behavioral sensitization
Alpha1-adrenergic receptor
Mice
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Associacao Fundo de Incentivo a Pesquisa(AFIP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Número do financiamento CNPq: 143273/2008-6
CNPq: 474601/2007-2
Data 2013-11-01
Publicado em Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 256, p. 646-654, 2013.
ISSN 0166-4328 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 646-654
Fonte http://dx.doi.org/10.1016/j.bbr.2013.09.015
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000328094100079
URI http://repositorio.unifesp.br/handle/11600/36937

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