Keratinized versus non-keratinized preputial flap onlay urethroplasty: does it make any difference in the histological analysis? An experimental study in rabbits

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dc.contributor.author Costa, Marnio [UNIFESP]
dc.contributor.author Leslie, Bruno [UNIFESP]
dc.contributor.author Rondon, Atila [UNIFESP]
dc.contributor.author Bacelar, Herick [UNIFESP]
dc.contributor.author Mattos, Ricardo [UNIFESP]
dc.contributor.author Barbosa, Bruno [UNIFESP]
dc.contributor.author Delcelo, Rosana [UNIFESP]
dc.contributor.author Ortiz, Valdemar [UNIFESP]
dc.contributor.author Macedo, Antonio [UNIFESP]
dc.date.accessioned 2016-01-24T14:34:38Z
dc.date.available 2016-01-24T14:34:38Z
dc.date.issued 2013-11-01
dc.identifier http://dx.doi.org/10.1590/S1677-5538.IBJU.2013.06.16
dc.identifier.citation International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 39, n. 6, p. 884-892, 2013.
dc.identifier.issn 1677-5538
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36916
dc.description.abstract Purpose: To compare the histological characteristics of keratinized versus non-keratinized onlay island flaps in an experimental rabbit model.Materials and Methods: Sixteen male rabbits were randomly allocated into two experimental groups: keratinized and non-keratinized onlay island flaps. A defect was created in the ventral aspect of the penile urethra. in the keratinized group, a longitudinal island flap was harvested from the external prepuce and rotated to cover the urethral defect. in the non-keratinized group a transverse island flap was harvested from the inner prepuce. the animals were sacrificed after 2, 4, 8 and 12 weeks.Results: the flaps were viable in all animals, and no deaths were associated with the procedure. Two urethrocutaneous fistulas were identified, one in each experimental group. A similar pattern of fibrosis was identified in both groups. the keratinized epithelium of the external prepuce kept its histological aspect and keratin production. Both keratinized and non-keratinized groups presented a slight decrease on the epithelial thickness, however without a statistically significant difference between groups.Conclusions: in this short-term rabbit model, we observed that the stratified squamous keratinized epithelium from the external prepuce kept its keratin production. There was no statistical influence of the flap type on the mean epithelial thickness. en
dc.format.extent 884-892
dc.language.iso eng
dc.publisher Brazilian Soc Urol
dc.relation.ispartof International Braz J Urol
dc.rights Acesso aberto
dc.subject Hypospadias en
dc.subject Surgical Flaps en
dc.subject Foreskin en
dc.subject Keratins en
dc.subject Urethra en
dc.title Keratinized versus non-keratinized preputial flap onlay urethroplasty: does it make any difference in the histological analysis? An experimental study in rabbits en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Div Urol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Div Urol, São Paulo, Brazil
dc.identifier.scielo S1677-5538.IBJU.2013.06.16
dc.identifier.doi 10.1590/S1677-5538.IBJU.2013.06.16
dc.description.source Web of Science
dc.identifier.wos WOS:000329979600016



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