The association between TNF-alpha and erectile dysfunction complaints

The association between TNF-alpha and erectile dysfunction complaints

Autor Matos, G. Autor UNIFESP Google Scholar
Hirotsu, C. Autor UNIFESP Google Scholar
Alvarenga, T. A. Autor UNIFESP Google Scholar
Cintra, F. Autor UNIFESP Google Scholar
Bittencourt, L. Autor UNIFESP Google Scholar
Tufik, S. Autor UNIFESP Google Scholar
Andersen, M. L. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Inflammatory markers like tumour necrosis factor-alpha (TNF-) have been related to erectile dysfunction (ED) and may interact with other cardiovascular risk factors such as obstructive sleep apnoea syndrome (OSAS). the aim of this study was to examine the inflammatory, metabolic and hormonal profile of men with or without ED complaints and/or OSAS recruited through the Epidemiologic Sleep Study (EPISONO). A sample of 363 men completed sexual questionnaires for ED and had physical and blood examinations. OSAS was evaluated by polysomnography and clinical assessment. the blood samples were used for determination of TNF-, interleukin-6, leptin, cholesterol and fractions, triglycerides, homocysteine, glucose and hormonal levels. After controlling for confounding factors, men with ED complaints presented higher systolic blood pressure and TNF-, independent of OSAS. Significant interaction between ED and OSAS was only observed for neck circumference, which was higher in ED men with OSAS than men with OSAS without ED and men with ED without OSAS. Binary logistic regression showed that the predictor factors for ED were age >43years, myocardial infarction events, TNF- and systolic blood pressure. Finally, a receiver-operating characteristics curve suggested a cut-off point of 9.95pg/mL for TNF- with sensitivity of 60% and specificity of 59% in men with ED complaints. Furthermore, there was a significant association between high levels of TNF- (>9.95pg/mL) and the presence of ED complaints. the results showed that there was an association between TNF- levels and ED complaints in men independent of OSAS.
Assunto age
cardiovascular disease
erectile dysfunction
sleep apnoea
TNF-alpha
Idioma Inglês
Financiador Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 10/15110-8
FAPESP: 10/50129-1
FAPESP: 11/12325-6
Data 2013-11-01
Publicado em Andrology. Hoboken: Wiley-Blackwell, v. 1, n. 6, p. 872-878, 2013.
ISSN 2047-2919 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 872-878
Fonte http://dx.doi.org/10.1111/j.2047-2927.2013.00136.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000326030400013
URI http://repositorio.unifesp.br/handle/11600/36905

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