Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer

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dc.contributor.author Resende, Wilson R.
dc.contributor.author Valvassori, Samira S.
dc.contributor.author Reus, Gislaine Z.
dc.contributor.author Varela, Roger B.
dc.contributor.author Arent, Camila O.
dc.contributor.author Ribeiro, Karine F.
dc.contributor.author Bavaresco, Daniela V.
dc.contributor.author Andersen, Monica L. [UNIFESP]
dc.contributor.author Zugno, Alexandra I.
dc.contributor.author Quevedo, Joao
dc.date.accessioned 2016-01-24T14:34:33Z
dc.date.available 2016-01-24T14:34:33Z
dc.date.issued 2013-10-01
dc.identifier http://dx.doi.org/10.1097/FBP.0b013e32836546fc
dc.identifier.citation Behavioural Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 24, n. 7, p. 569-579, 2013.
dc.identifier.issn 0955-8810
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36853
dc.description.abstract Bipolar disorder is a severe mood disorder with high morbidity and mortality. Despite adequate treatment, patients continue to have recurrent mood episodes, residual symptoms, and functional impairment. Some preclinical studies have shown that histone deacetylase inhibitors may act on depressive-like and manic-like behaviors. Therefore, the aim of the present study was to evaluate the effects of sodium butyrate (SB) on behavioral changes in animal models of depression and mania. the animals were submitted to protocols of chronic mild stress or maternal deprivation for induction of depressive-like behaviors and subjected to amphetamine, or ouabain administration for induction of manic-like behaviors. SB reversed the depressive-like and manic-like behaviors evaluated in the animal models. From these results we can suggest that SB may be a potential mood stabilizer. (C) 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship FAPESC
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship UNESC
dc.format.extent 569-579
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Behavioural Pharmacology
dc.rights Acesso restrito
dc.subject animal model en
dc.subject bipolar disorder en
dc.subject depression en
dc.subject mania en
dc.subject rat en
dc.subject sodium butyrate en
dc.title Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer en
dc.type Artigo
dc.contributor.institution Univ Southern Santa Catarina
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Southern Santa Catarina, Natl Inst Translat Med INCT TM, Neurosci Lab, Grad Program Hlth Sci,Hlth Sci Unit, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliation Univ Southern Santa Catarina, Ctr Excellence Appl Neurosci Santa Catarina NENAS, Grad Program Hlth Sci, Hlth Sci Unit, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.identifier.doi 10.1097/FBP.0b013e32836546fc
dc.description.source Web of Science
dc.identifier.wos WOS:000326971200004



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