Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer

Effects of sodium butyrate in animal models of mania and depression: implications as a new mood stabilizer

Author Resende, Wilson R. Google Scholar
Valvassori, Samira S. Google Scholar
Reus, Gislaine Z. Google Scholar
Varela, Roger B. Google Scholar
Arent, Camila O. Google Scholar
Ribeiro, Karine F. Google Scholar
Bavaresco, Daniela V. Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Zugno, Alexandra I. Google Scholar
Quevedo, Joao Google Scholar
Institution Univ Southern Santa Catarina
Universidade Federal de São Paulo (UNIFESP)
Abstract Bipolar disorder is a severe mood disorder with high morbidity and mortality. Despite adequate treatment, patients continue to have recurrent mood episodes, residual symptoms, and functional impairment. Some preclinical studies have shown that histone deacetylase inhibitors may act on depressive-like and manic-like behaviors. Therefore, the aim of the present study was to evaluate the effects of sodium butyrate (SB) on behavioral changes in animal models of depression and mania. the animals were submitted to protocols of chronic mild stress or maternal deprivation for induction of depressive-like behaviors and subjected to amphetamine, or ouabain administration for induction of manic-like behaviors. SB reversed the depressive-like and manic-like behaviors evaluated in the animal models. From these results we can suggest that SB may be a potential mood stabilizer. (C) 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Keywords animal model
bipolar disorder
sodium butyrate
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2013-10-01
Published in Behavioural Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 24, n. 7, p. 569-579, 2013.
ISSN 0955-8810 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 569-579
Origin http://dx.doi.org/10.1097/FBP.0b013e32836546fc
Access rights Closed access
Type Article
Web of Science ID WOS:000326971200004
URI http://repositorio.unifesp.br/handle/11600/36853

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