Inactivation of muscarinic receptors impairs place and response learning: Implications for multiple memory systems

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dc.contributor.author Kramer Soares, Juliana Carlota [UNIFESP]
dc.contributor.author Menezes Oliveira, Maria Gabriela [UNIFESP]
dc.contributor.author Ferreira, Tatiana Lima [UNIFESP]
dc.date.accessioned 2016-01-24T14:34:32Z
dc.date.available 2016-01-24T14:34:32Z
dc.date.issued 2013-10-01
dc.identifier http://dx.doi.org/10.1016/j.neuropharm.2013.06.009
dc.identifier.citation Neuropharmacology. Oxford: Pergamon-Elsevier B.V., v. 73, p. 320-326, 2013.
dc.identifier.issn 0028-3908
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36832
dc.description.abstract Extensive research has shown that the hippocampus and striatum have dissociable roles in memory and are necessary for place and response learning, respectively. Additional evidence indicates that muscarinic cholinergic receptors in the hippocampus and striatum exert an important role in the modulation of these memory systems. in our experiments, we assessed whether intact hippocampal and striatal muscarinic cholinergic transmission may be essential and/or necessary for place and response learning. We addressed these questions using administration of the muscarinic receptor antagonist, scopolamine, on both place and response learning in a food-rewarded T-maze task. the administration of scopolamine (15 mu g or 30 mu g) directly into the dorsal hippocampus impaired the performance of rats subjected to both place and cue-rich response version of the task, but did not affect the response version, when the task was performed under cue-poor conditions. However, the administration of scopolamine in the dorsolateral striatum impaired the cue-poor response version of the T-maze task without interfering with the place version or cue-rich response version. Taken together, these results indicate that activation of muscarinic cholinergic receptors in the hippocampus and striatum facilitate the use of different strategies of learning, thus strengthening the hypothesis of multiple memory systems. Additionally, these results emphasize the importance of the environmental conditions under which tasks are performed. (C) 2013 Elsevier B.V. All rights reserved. en
dc.description.sponsorship AFIP
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 320-326
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Neuropharmacology
dc.rights Acesso restrito
dc.subject Scopolamine en
dc.subject Muscarinic receptors en
dc.subject Hippocampus en
dc.subject Striatum en
dc.subject Place learning en
dc.subject Response learning en
dc.subject Maze en
dc.title Inactivation of muscarinic receptors impairs place and response learning: Implications for multiple memory systems en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal do ABC (UFABC)
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliation Univ Fed Abc, Ctr Matemat Computacao & Cognicao, Santo Andre, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.identifier.doi 10.1016/j.neuropharm.2013.06.009
dc.description.source Web of Science
dc.identifier.wos WOS:000325233300031



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