Inactivation of muscarinic receptors impairs place and response learning: Implications for multiple memory systems

Inactivation of muscarinic receptors impairs place and response learning: Implications for multiple memory systems

Author Kramer Soares, Juliana Carlota Autor UNIFESP Google Scholar
Menezes Oliveira, Maria Gabriela Autor UNIFESP Google Scholar
Ferreira, Tatiana Lima Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC (UFABC)
Abstract Extensive research has shown that the hippocampus and striatum have dissociable roles in memory and are necessary for place and response learning, respectively. Additional evidence indicates that muscarinic cholinergic receptors in the hippocampus and striatum exert an important role in the modulation of these memory systems. in our experiments, we assessed whether intact hippocampal and striatal muscarinic cholinergic transmission may be essential and/or necessary for place and response learning. We addressed these questions using administration of the muscarinic receptor antagonist, scopolamine, on both place and response learning in a food-rewarded T-maze task. the administration of scopolamine (15 mu g or 30 mu g) directly into the dorsal hippocampus impaired the performance of rats subjected to both place and cue-rich response version of the task, but did not affect the response version, when the task was performed under cue-poor conditions. However, the administration of scopolamine in the dorsolateral striatum impaired the cue-poor response version of the T-maze task without interfering with the place version or cue-rich response version. Taken together, these results indicate that activation of muscarinic cholinergic receptors in the hippocampus and striatum facilitate the use of different strategies of learning, thus strengthening the hypothesis of multiple memory systems. Additionally, these results emphasize the importance of the environmental conditions under which tasks are performed. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Scopolamine
Muscarinic receptors
Hippocampus
Striatum
Place learning
Response learning
Maze
Language English
Sponsor AFIP
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-10-01
Published in Neuropharmacology. Oxford: Pergamon-Elsevier B.V., v. 73, p. 320-326, 2013.
ISSN 0028-3908 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 320-326
Origin http://dx.doi.org/10.1016/j.neuropharm.2013.06.009
Access rights Closed access
Type Article
Web of Science ID WOS:000325233300031
URI http://repositorio.unifesp.br/handle/11600/36832

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