Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia

Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia

Author Asevedo, Elson Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Noto, Cristiano Autor UNIFESP Google Scholar
Mansur, Rodrigo B. Autor UNIFESP Google Scholar
Zugman, Andre Autor UNIFESP Google Scholar
Belangero, Sintia I. N. Autor UNIFESP Google Scholar
Berberian, Arthur A. Autor UNIFESP Google Scholar
Scarpato, Bruno S. Autor UNIFESP Google Scholar
Leclerc, Emilie Autor UNIFESP Google Scholar
Teixeira, Antonio L. Google Scholar
Gama, Clarissa S. Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Minas Gerais (UFMG)
Univ Fed Rio Grande do Sul
Abstract Objective: To investigate possible differences in peripheral levels of chemokines, BDNF and oxidative markers between patients with Schizophrenia (SZ) and matched healthy controls, and investigate the correlation of these biomarkers with cognitive performance.Methods: Thirty individuals with SZ and 27 healthy controls were included and the following plasmatic biomarkers' levels were determined according to manufacturers' instructions: BDNF, TBARS, protein carbonyl content (PCC) and the chemokines CXCL-10/IP-10, CXCL-8/IL-8, CCL-11, CCL-24/Eotaxin-2, CCL-2/MCP-1, CCL-3/MIP-1. Selected neuropsychological tasks were administered to assess verbal learning (Hopkins Verbal Learning Test), verbal fluency (FAS test), working memory (Visual Working Memory Task, Keep Track Task, Letter Memory Task), set shifting (Plus minus task, Number letter task), inhibition (Computerized Stroop Task, Semantic Generation Task) and complex executive function tasks (Tower of London and the shortened version of the WCST-64).Results: Compared with the healthy control group, individuals with SZ presented significantly higher levels of BDNF and the chemokine CCL-11, and lower levels of TSARS and the chemokine CXCL-10/IP-10. When we examined only the SZ group, BDNF levels were positively correlated with semantic generation tasks. Working memory ability was negatively correlated with PCC. Regarding chemokines, CCL-11 was negatively correlated to performance in working memory test, and positively correlated with cognitive flexibility task. CXCL-8/IL-8 was positively correlated with verbal fluency. CCL-24/Eotaxin-2 was positively correlated with semantic generation ability and letter memory task.Conclusions: Our results indicate that cognitive performance in SZ is associated with mediators of neuroplasticity that can be measured peripherally. (C) 2013 Elsevier B.V. All rights reserved.
Keywords Schizophrenia
Cognition
BDNF
Chemokines
Oxidative stress
Biomarkers
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2013-10-01
Published in Journal of Psychiatric Research. Oxford: Pergamon-Elsevier B.V., v. 47, n. 10, p. 1376-1382, 2013.
ISSN 0022-3956 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1376-1382
Origin http://dx.doi.org/10.1016/j.jpsychires.2013.05.032
Access rights Closed access
Type Article
Web of Science ID WOS:000324004700014
URI http://repositorio.unifesp.br/handle/11600/36826

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