Effects of unilateral stereotactic posterior striatotomy on harmaline-induced tremor in rats

Effects of unilateral stereotactic posterior striatotomy on harmaline-induced tremor in rats

Author Vilela Filho, Osvaldo Autor UNIFESP Google Scholar
Ferraz, Fernando P. Autor UNIFESP Google Scholar
Barros, Breno A. Google Scholar
Silva, Luciana O. Google Scholar
Anunciacao, Suzana F. Google Scholar
Souza, Joaquim T. Google Scholar
Silva, Delson J. Google Scholar
Leite, Mauricio B. Google Scholar
Atayde, Ingrid B. Google Scholar
Ragazzo, Paulo C. Google Scholar
Barreto, Paula G. Google Scholar
Nobrega, Mariana A. Google Scholar
Araujo, Maisa R. Google Scholar
Santos, Mayra R. Google Scholar
Ala, Victor H. Google Scholar
Queiroz, Stefano T. Google Scholar
Institution Universidade Federal de Goiás (UFG)
Universidade Federal de São Paulo (UNIFESP)
Pontifical Catholic Univ Goias
Goiania Neurol Inst
Abstract Although long known and the most prevalent movement disorder, pathophysiology of essential tremor (ET) remains controversial. the most accepted hypothesis is that it is caused by a dysfunction of the olivocerebellar system. Vilela Filho et al. [2001; Stereotact Funct Neurosurg 77:149-150], however, reported a patient with unilateral hand ET that was completely relieved after a stroke restricted to the contralateral posterior putamen and suggested that ET could be the clinical manifestation of posterior putamen hyperactivity. the present study was designed to evaluate this hypothesis in the most often used model of ET, harmaline-induced tremor in rats. Fifty-four male Wistar rats were randomly distributed into three groups: experimental (EG), surgical control (SCG), and pharmacological control (PCG) groups. EG animals underwent stereotactic unilateral posterior striatotomy. SCG rats underwent sham lesion at the same target. PCG served exclusively as controls for harmaline effects. All animals received, postoperatively, intraperitoneal harmaline, and the induced tremor was video-recorded for later evaluation by a blind observer. Thirteen animals were excluded from the study. Limb tremor was reduced ipsilaterally to the operation in 20 of 21 rats of EG and in two of nine of SCG, being asymmetric in one of 10 of PCG rats. Comparisons between EG x SCG and EG x PCG were statistically significant, but not between SCG x PCG. Limb tremor reduction was greater in anterior than in posterior paws. Lateral lesions yielded better results than medial lesions. These results suggest that the posterior striatum is involved with harmaline-induced tremor in rats and support the hypothesis presented. (c) 2013 Wiley Periodicals, Inc.
Keywords harmaline
tremor
essential tremor
striatum
electrolytic lesion
Language English
Date 2013-10-01
Published in Journal of Neuroscience Research. Hoboken: Wiley-Blackwell, v. 91, n. 10, p. 1328-1337, 2013.
ISSN 0360-4012 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1328-1337
Origin http://dx.doi.org/10.1002/jnr.23249
Access rights Closed access
Type Article
Web of Science ID WOS:000323394400008
URI http://repositorio.unifesp.br/handle/11600/36791

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