Identification of upregulated genes in oral squamous cell carcinomas

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dc.contributor.author Lessa, Roberta C.
dc.contributor.author Campos, Antonio Hugo J. F. M.
dc.contributor.author Freitas, Carlos Elias de
dc.contributor.author Silva, Felipe Rodrigues da
dc.contributor.author Kowalski, Luiz Paulo
dc.contributor.author Carvalho, Andre Lopes
dc.contributor.author Vettore, Andre Luiz [UNIFESP]
dc.date.accessioned 2016-01-24T14:34:28Z
dc.date.available 2016-01-24T14:34:28Z
dc.date.issued 2013-10-01
dc.identifier http://dx.doi.org/10.1002/hed.23169
dc.identifier.citation Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. Hoboken: Wiley-Blackwell, v. 35, n. 10, p. 1475-1481, 2013.
dc.identifier.issn 1043-3074
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36789
dc.description.abstract BackgroundOral cancer is the most common subset of head and neck squamous cell carcinomas (HNSCC). These tumors often have an aggressive clinical outcome hallmarked by a propensity for local invasion and regional nodal metastasis. Upregulated genes could be useful as markers for diagnosis, prognosis, and as new drug targets for these tumors.MethodsTo identify upregulated genes in oral squamous cell carcinomas (OSSCs), we examined the ORESTES public database and used a quantitative reverse transcription-polymerase chain reaction (qRT-PCR) approach to determine the expression level of selected genes in tumor samples.Results and ConclusionsThe ORESTES data mining analysis indicated 40 upregulated genes in HNSCC. Nine of these candidate genes were selected for further qRT-PCR validation and 3 of them (ALDOA, AHSA1, and POLQ) were frequently found upregulated in OSCC samples, which may indicate an association of these genes with the carcinogenesis process in this tumor site and they can constitute potential new targets for therapy. (c) 2012 Wiley Periodicals, Inc. Head Neck 35: 1475-1481, 2013 en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Fundacao Antonio Prudente (FAP)
dc.format.extent 1475-1481
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Head and Neck-Journal for the Sciences and Specialties of the Head and Neck
dc.rights Acesso restrito
dc.subject head and neck squamous cell carcinoma en
dc.subject upregulation en
dc.subject quantitative RT-PCR en
dc.title Identification of upregulated genes in oral squamous cell carcinomas en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution AC Camargo Canc Hosp
dc.contributor.institution Ludwig Inst Canc Res
dc.contributor.institution Bahia Sch Med & Publ Hlth
dc.contributor.institution Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributor.institution Barretos Canc Hosp
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation AC Camargo Canc Hosp, Dept Head & Neck Surg, São Paulo, Brazil
dc.description.affiliation Ludwig Inst Canc Res, São Paulo Branch, São Paulo, Brazil
dc.description.affiliation AC Camargo Canc Hosp, Dept Pathol, São Paulo, Brazil
dc.description.affiliation Bahia Sch Med & Publ Hlth, Salvador, BA, Brazil
dc.description.affiliation Embrapa Informat Agr, Campinas, SP, Brazil
dc.description.affiliation Barretos Canc Hosp, Dept Head & Neck Surg, Barretos, Brazil
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dept Sci Biol, São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dept Sci Biol, São Paulo, Brazil
dc.description.sponsorshipID CNPq: 476586/2006-2
dc.description.sponsorshipID FAPESP: 05/02580-8
dc.description.sponsorshipID CNPq: 302360/2008-5
dc.description.sponsorshipID CNPq: 308732/2011-1
dc.description.sponsorshipID CNPq: 313181/2009-8
dc.identifier.doi 10.1002/hed.23169
dc.description.source Web of Science
dc.identifier.wos WOS:000325091000028



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