Extracellular vesicles: structure, function, and potential clinical uses in renal diseases

Extracellular vesicles: structure, function, and potential clinical uses in renal diseases

Author Borges, Fernanda Teixeira Autor UNIFESP Google Scholar
Reis, L. A. Autor UNIFESP Google Scholar
Schor, Nestor Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Cruzeiro Sul
Abstract Interest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40- 100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. the therapeutic potential of extracellular vesicles is very broad, with applications including a route of drug delivery and as biomarkers for diagnosis. Extracellular vesicles extracted from stem cells may be used for treatment of many diseases including kidney diseases. This review highlights mechanisms of synthesis and function, and the potential uses of wellcharacterized extracellular vesicles, mainly exosomes, with a special focus on renal functions and diseases.
Keywords Extracellular vesicles
Cell biology
Kidney diseases
Diagnosis
Treatment
Language English
Date 2013-10-01
Published in Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 10, p. 824-830, 2013.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 824-830
Origin http://dx.doi.org/10.1590/1414-431X20132964
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000326015700002
SciELO ID S0100-879X2013001000824 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/36785

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