Speech and orofacial apraxias in Alzheimer's disease

Speech and orofacial apraxias in Alzheimer's disease

Author Cera, Maysa Luchesi Autor UNIFESP Google Scholar
Ortiz, Karin Zazo Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Minett, Thaís Soares Cianciarullo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Alzheimer's disease (AD) affects not only memory but also other cognitive functions, such as orientation, language, praxis, attention, visual perception, or executive function. Most studies on oral communication in AD focus on aphasia; however, speech and orofacial apraxias are also present in these patients. the aim of this study was to investigate the presence of speech and orofacial apraxias in patients with AD with the hypothesis that apraxia severity is strongly correlated with disease severity.Methods: Ninety participants in different stages of AD (mild, moderate, and severe) underwent the following assessments: Clinical Dementia Rating, Mini-Mental State Examination, Lawton Instrumental Activities of Daily Living, a specific speech and orofacial praxis assessment, and the oral agility subtest of the Boston diagnostic aphasia examination.Results: the mean age was 80.2 +/- 7.2 years and 73% were women. Patients with AD had significantly lower scores than normal controls for speech praxis (mean difference = -2.9, 95% confidence interval (CI) = -3.3 to -2.4) and orofacial praxis (mean difference = -4.9, 95% CI = -5.4 to -4.3). Dementia severity was significantly associated with orofacial apraxia severity (moderate AD: beta = -19.63, p = 0.011; and severe AD: beta = -51.68, p < 0.001) and speech apraxia severity (moderate AD: beta = 7.07, p = 0.001; and severe AD: beta = 8.16, p < 0.001).Conclusion: Speech and orofacial apraxias were evident in patients with AD and became more pronounced with disease progression.
Keywords apraxias
Alzheimer's disease
articulation disorders
Language English
Date 2013-10-01
Published in International Psychogeriatrics. New York: Cambridge Univ Press, v. 25, n. 10, p. 1679-1685, 2013.
ISSN 1041-6102 (Sherpa/Romeo, impact factor)
Publisher Cambridge Univ Press
Extent 1679-1685
Origin http://dx.doi.org/10.1017/S1041610213000781
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000323522400011
URI http://repositorio.unifesp.br/handle/11600/36775

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