The anti-inflammatory potential of phenolic compounds in grape juice concentrate (G8000 (TM)) on 2,4,6-trinitrobenzene sulphonic acid-induced colitis

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dc.contributor.author Ribeiro Paiotti, Ana Paula [UNIFESP]
dc.contributor.author Neto, Ricardo Artigiani [UNIFESP]
dc.contributor.author Marchi, Patricia [UNIFESP]
dc.contributor.author Silva, Roseane Mendes [UNIFESP]
dc.contributor.author Pazine, Vanessa Lima [UNIFESP]
dc.contributor.author Noguti, Juliana [UNIFESP]
dc.contributor.author Pastrelo, Mauricio Mercaldi [UNIFESP]
dc.contributor.author Boiago Golluecke, Andrea Pittelli
dc.contributor.author Miszputen, Sender Jankiel [UNIFESP]
dc.contributor.author Ribeiro, Daniel Araki [UNIFESP]
dc.date.accessioned 2016-01-24T14:34:26Z
dc.date.available 2016-01-24T14:34:26Z
dc.date.issued 2013-09-28
dc.identifier http://dx.doi.org/10.1017/S000711451300007X
dc.identifier.citation British Journal of Nutrition. Cambridge: Cambridge Univ Press, v. 110, n. 6, p. 973-980, 2013.
dc.identifier.issn 0007-1145
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/36766
dc.description.abstract Chronic inflammatory bowel disease is characterised by an up-regulation of the synthesis and release of a variety of pro-inflammatory mediators leading to excessive tissue injury. Flavonoids are able to inhibit enzymes and/or due to their antioxidant properties regulate the immune response. the goal of the present study was to evaluate the mechanisms of action of phenolic compounds present in grape juice on 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. A total of forty-one male Wistar rats were randomised into seven groups: negative control group; TNBS non-treated induced colitis; 2% grape juice control group; 1% grape juice 24 h after TNBS colitis induction; 1% grape juice on day 7 after colitis induction; 2% grape juice 24 h after colitis induction; 2% grape juice on day 7 after colitis induction. the 1% grape juice-treated induced colitis group showed marked clinical improvement when compared with the TNBS-induced colitis group. Rats that received 1% grape juice, on day 7 after colitis induction, presented reduced intensity of macroscopic and histological scores. Statistically significant differences (P<0.05) of TNF-alpha and inducible NO synthase mRNA expression were detected in the groups treated with grape juice at the 1% dose after inducing experimental colitis when compared with the TNBS group. Grape juice reduced the noxious effects induced by colitis caused by TNBS, especially at the 1% dose. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 973-980
dc.language.iso eng
dc.publisher Cambridge Univ Press
dc.relation.ispartof British Journal of Nutrition
dc.rights Acesso restrito
dc.subject 2,4,6-Trinitrobenzene sulphonic acid-induced colitis en
dc.subject Grape juice en
dc.subject TNF-alpha en
dc.subject Inducible nitric oxide synthase en
dc.subject Intercellular adhesion molecule-1 en
dc.subject NF-kappa B en
dc.title The anti-inflammatory potential of phenolic compounds in grape juice concentrate (G8000 (TM)) on 2,4,6-trinitrobenzene sulphonic acid-induced colitis en
dc.type Artigo
dc.rights.license http://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Estadual de Campinas (UNICAMP)
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Escola Paulista Med, Dept Pathol, Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, UNIFESP, Escola Paulista Med, Div Gastroenterol, Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biosci, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.description.affiliation Univ Estadual Campinas, UNICAMP, Food Engn Fac, Dept Food & Nutr, Campinas, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Escola Paulista Med, Dept Pathol, Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, UNIFESP, Escola Paulista Med, Div Gastroenterol, Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biosci, UNIFESP, BR-11060001 Santos, SP, Brazil
dc.identifier.doi 10.1017/S000711451300007X
dc.description.source Web of Science
dc.identifier.wos WOS:000323848700001



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