Vertebral bone density by quantitative computed tomography mirrors bone structure histomorphometric parameters in hemodialysis patients

Vertebral bone density by quantitative computed tomography mirrors bone structure histomorphometric parameters in hemodialysis patients

Author Carvalho, Aluizio Barbosa Autor UNIFESP Google Scholar
Carneiro, Ricardo Autor UNIFESP Google Scholar
Leme, Graziella M. Autor UNIFESP Google Scholar
Rochitte, Carlos E. Autor UNIFESP Google Scholar
Santos, Raul D. Autor UNIFESP Google Scholar
Miname, Marcio H. Autor UNIFESP Google Scholar
Moyses, Rosa M. Autor UNIFESP Google Scholar
Jorgetti, Vanda Autor UNIFESP Google Scholar
Canziani, Maria Eugnia F. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Diagnosing low bone mass is of clinical importance for hemodialysis (HD) patients due to its association with fractures and cardiovascular disease. We investigated whether bone density obtained by quantitative computed tomography (QCT) is associated with the histologically determined bone volume and microarchitecture parameters in HD patients. Twenty-six HD patients were studied. Bone biopsy samples were obtained from the iliac crest and trabecular bone volume, thickness, number and separation were evaluated by histomorphometry. Vertebral trabecular bone density (VTBD) was evaluated by QCT. VTBD correlated positively with trabecular bone volume (r = 0.69, p < 0.001), trabecular thickness (r = 0.45, p = 0.022) and trabecular number (r = 0.62, p < 0.001), and negatively with trabecular separation (r = -0.50, p < 0.01). in the multiple linear regression analysis adjusting for age, gender and diabetes, VTBD remained associated with bone volume by histomorphometry (beta = 0.06; 95 % CI 0.02-0.11; p = 0.006; R (2) = 0.49). VTBD measured by QCT mirrored bone volume and microarchitecture parameters obtained by histomorphometry in HD patients.
Keywords Bone density
Quantitative computed tomography
Bone biopsy
Histomorphometry
Hemodialysis
Language English
Date 2013-09-01
Published in Journal of Bone and Mineral Metabolism. Tokyo: Springer Japan Kk, v. 31, n. 5, p. 551-555, 2013.
ISSN 0914-8779 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 551-555
Origin http://dx.doi.org/10.1007/s00774-013-0442-0
Access rights Closed access
Type Article
Web of Science ID WOS:000325113500008
URI http://repositorio.unifesp.br/handle/11600/36695

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account