Acylated ghrelin: A potential marker for fibromyalgia?

Acylated ghrelin: A potential marker for fibromyalgia?

Author Homann, D. Google Scholar
Louzada, F. M. Google Scholar
Goes, S. M. Google Scholar
Roizenblatt, S. Autor UNIFESP Google Scholar
Lopes, A. L. Google Scholar
Oliveira, A. R. de Google Scholar
Leite, N. Google Scholar
Institution Univ Fed Parana
Universidade Federal de São Paulo (UNIFESP)
Univ Fed Rio Grande do Sul
Abstract Background: Fibromyalgia is characterized by chronic widespread pain and sleep disturbances. Overweight and obesity, which lead to metabolic changes, are additional comorbidities that are rarely explored, although they are highly prevalent in patients with fibromyalgia.Methods: We compared the plasma levels of leptin and acylated ghrelin in 17 women with fibromyalgia (patients) and 16 healthy women (controls) with similar age, anthropometric measurements and levels of physical activity. We also investigated the relationships between these two neuropeptides and sleep and various pain characteristics in patients with fibromyalgia. Anthropometric measurements were recorded, and physical activity levels were assessed using a questionnaire. Pain intensity was measured using visual analogue scales (weekly general and mean pain scores). Sleep was assessed using an accelerometry technique.Results: Compared to the control group, the patient group had increased leptin levels (patients: 22.4 +/- 10.6 vs. controls: 13.3 +/- 17.9 ng/mL; p < 0.01) and decreased acylated ghrelin levels (patients: 126.7 +/- 47.8 vs. controls: 183.3 +/- 102.2 pg/mL; p = 0.048). the leptin level was not significantly correlated with any of the variables. Acylated ghrelin level was inversely correlated with the weekly mean pain score (r = -0.67, p < 0.01) and the weekly general pain score (r = -0.67, p < 0.01). Multiple regression analysis revealed that the variations in acylated ghrelin levels accounted for 35% of the weekly general pain and 29% of the weekly mean pain variability.Conclusions: These findings indicate that the decreased acylated ghrelin levels in women with fibromyalgia are related to pain intensity.
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2013-09-01
Published in European Journal of Pain. Hoboken: Wiley-Blackwell, v. 17, n. 8, p. 1216-1224, 2013.
ISSN 1090-3801 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1216-1224
Origin http://dx.doi.org/10.1002/j.1532-2149.2013.00296.x
Access rights Closed access
Type Article
Web of Science ID WOS:000322723600013
URI http://repositorio.unifesp.br/handle/11600/36688

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